Štúdium éterických olejov a ich zložiek z hľadiska ich ochranného pôsobenia v procese iniciácie nádorového ochorenia; experimentálne systémy in vitro a ex vivo
Study of essential oils and their components from the point of view of the protective action in the initiation step of carcinogenesis; experimental systems in vitro and ex vivo
Program: VEGA
Project leader: Ing. Navarová Jana, PhD.
Annotation: DNA damage connected with different changes on the genetic level is at present considered to be the most significant stimulus of initiation of the process of carcinogenesis. Study of antimutagenic and anticarcinogenic effects of natural compounds, which are frequently used in different areas of human life, is therefore of great importance. In the framework of the proposed project we intend 1 to ascertain the antioxidant potential of selected essential oils and their components by biochemical methods; 2 to assess their antimutagenic activity by applying in vitro systems using mammalian cells, bacteria, yeast and algae; 3 on using an ex vivo approach todetermine whether the cells freshly isolated from experimental rats which obtained the compounds studied in drinking water would manifest DNA-protective effects; 4 in cell extracts obtained from cells of animals kept at anormal or modified drinking regimen to investigate repair enzymatic activity and activities of some of the most important cellular enzymes.
Duration: 1.1.2009 – 31.12.2011