Projects

International

Protizápalový účinok prírodných látok izolovaných z vietnamských liečivých rastlín
Anti-inflammatory effects of natural compounds isolated from Vietnam medicinal plants
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2020 – 31.12.2022
Protizápalový účinok prírodných látok izolovaných z vietnamských liečivých rastlín
Anti-inflammatory effects of natural compounds isolated from Vietnam medicinal plants
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Annotation: Objectives of this project are as follows: – Screening of selected Vietnamese medicinal plants and natural compounds for in vitro anti-inflammatory activity; – Identification of mechanisms of action of the most bioactive compounds with anti-inflammatory activity using in vitro and in vivo methods (preferably model of adjuvant arthritis in rats).
Duration: 1.4.2020 – 31.12.2022
SKPTPHARMACOL – Spolupráca na komplexnom hodnotení farmakologického ovplyvnenia zápalových ochorení pohybového aparátu a gastrointestinálneho traktu na experimentálnych zvieracích modeloch
Collaboration on a complex pharmacological assessment of inflammatory diseases of the musculo-skeletal system and gastrointestinal tract on experimental animal models
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Annotation: Animal models have been used to study inflammatory diseases for almost a century. Our innovative approach in the research of inflammation and autoimmunity of the musculoskeletal and gastrointestinal tract is to use simultaneously multiple experimental models with well-known pathophysiology (i.e.: Collagen type-II-induced arthritis, Adjuvant-induced arthritis, Carrageenan induced oedema and trinitrobenzenesulfonic acid induced colitis). This enables us to better understand and describe the pharmacodynamic mode of action of experimental treatments approximately to human disease. Selected active substances studied on several models mentioned above, can bring us to deeper elucidation of mechanism of action. Moreover, the combination of substances studied together with an appropriate disease modifying anti-rheumatic drug may improve the standard treatment of inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. The main outputs of this project will be to meet on our workplaces, sharing methodology and results analysis to create the proposal for future cooperation in between Slovakia and Portugal. In parallel we also plan to manage two bilateral conferences and to engage our PhD students and post-docs to this project. During the duration of this project we will seek for possibilities how to be a part of a multilateral and EU project network.
Duration: 1.1.2019 – 31.12.2022
Anti-inflammatory effect of astaxanthin, sulforaphane and Crocus sativus extract evaluated in two rodent models of age related diseases.
Program: Inter-academic agreement
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Annotation: In this collaborative project, we would like to establish the animal model of CIOA in Balb/c mice. One of the aims of the proposal is to study the pathogenesis of before-mentioned disease and the development of joint changes in CIOA during treatment by selected antioxidants. Groups of CIOA-Balb/c mice will be treated with astaxanthin, sulforaphane and Crocus sativus extract. We will determine the levels of selected pro- and anti-inflammatory mediators and the phenotype of cells in the synovial extracts and sera as well as the histology changes after treatment. We expect, that after treatment of CIOA-mice, many of the observed parameters will be improved. The second rodent model used will be Lewis rats with induced arthritis (AA).
Duration: 1.1.2018 – 30.6.2021
Evaluation of Quercetin and Green Tea in combination with Methotrexate for arthritis therapy (Acronym: PhytoArt 2.0)
Evaluation of Quercetin and Green Tea in combination with Methotrexate for arthritis therapy (Acronym: PhytoArt 2.0)
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2016 – 31.12.2017
Phytochemicals in ameliorating rheumatoid arthritis therapy: from preclinical studies to clinical applications
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2013 – 31.12.2015
Role of the systemic inflammatory processes in the development of oxidative stress in the brain of arthritic subjects. Evaluation of experimental therapy based on new carnosine preparations
Role of the systemic inflammatory processes in the development of oxidative stress in the brain of arthritic subjects. Evaluation of experimental therapy based on new carnosine preparations
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2013 – 31.12.2015
In vitro and in vivo models of arthritic processes for studying the mechanisms of inflammation and oxidative stress link-up. New perspectives for arthritis therapy
In vitro and in vivo models of arthritic processes for studying the mechanisms of inflammation and oxidative stress link-up. New perspectives for arthritis therapy
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2010 – 31.12.2012
Regulation of cytokine synthesis during inflammation develoment in brain and other tissues
Regulation of cytokine synthesis during inflammation develoment in brain and other tissues
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2010 – 31.12.2012

National

Hodnotenie a porovnanie protizápalovej a antioxidačnej účinnosti karotenoidov in vitro a in vivo pomocou modelov chronických zápalových ochorení.
Program: VEGA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2020 – 31.12.2023
Nové prístupy k liečbe kachexie, zápalu a oxidačného stresu v experimentálnej artritíde: Účinok rôznych rastlinných extraktov z olivových listov, Rhodiola rosea, Tribulus terrestris a extra panenského olivového oleja
Program: VEGA
Project leader: PharmDr. Poništ Silvester, PhD.
Duration: 1.1.2019 – 31.12.2021
Molekulárno-farmakologické prístupy k inovatívnej terapii reumatoidnej artritídy hodnotenej v experimentálnych podmienkach in vivo a in vitro
Program: SRDA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.7.2016 – 30.6.2020
Názov projektu: Výskum ovplyvnenia zápalu, chronickej autoimunitnej reakcie a redoxnej regulácie organizmu v experimentálnej artritíde použitím nových látok pre adjuvantnú terapiu reumatoidnej artritídy
Program: VEGA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2015 – 31.12.2018
Štúdium kombinácie imunosupresívnej liečby a ovplyvnenia redoxnej rovnováhy organizmu na zvieracích modeloch reumatoidnej artritídy
Study of combination of immunosuppressive treatment and substances affecting redox balance of organism on animal models of rheumatoid arthritis
Program: VEGA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Annotation: The focus of the project will be the study of the therapeutic potential of the substances with anti-oxidative properties within RA therapy, and in particular of MTX combined therapy. The adjuvant arthritis (AA) model will be used in Lewis rats. AA progress and its pharmacological influencing will be characterized by parameters expressing immunological, oxidative, and inflammatory processes. The chronic AA model will be supplemented by the model of inflammation induced by carrageenan, as well as by the study of substances evaluated in macrophage cell culture.For potential utilization in combined RA therapy, the following substances will be evaluated: carnosine and its acetyled derivative, natural polysaccharides, low-molecular antioxidants with thiol groups, herbal antioxidants, and anti-inflammatory antihistaminics. Evaluation in vivo of the aforementioned substances will take place after the in vitro analysis of the anti-oxidative efficiency in two independent models
Duration: 1.1.2011 – 31.12.2014
Farmakológia neu – Celulárne a molekulárne aspekty farmakologickej regulácie prozápalovej aktivity neutrofilov
Cellular and molecular aspects of pharmacological regulation of neutrophil pro-inflammatory activity
Program: SRDA
Project leader: prof. MUDr. Nosáľ Radomír, DrSc.
Annotation: Unique research is focussed on the role of neutrophil leukocytes in proinflammatory processes of the organism with respect to mechanisms of their activation at cellular and molecular level. At present the target is the role of neutrophils in important pathophysiological units like ischaemia-reperfusion damage of the heart and brain, as well as nonspecific inflammatory processes (rheumatoid polyarthritis), diabetes, carcinoma, atherosclerosis, etc. We shall concentrate our studies on the mechanisms of oxidative burst in isolated neutrophils, their responses in whole blood and tissues as well as on processes in connection with their activation and apoptosis, at the level of reactive oxygen species, enzyme activation and expression od proinflammatory active substances. Original results will enrich the knowledge on the role of neutrophils in the process of adjuvant arthritis and its pharmaco-therapeutic intervention. Our attention is focussed first of all on substances of natural origin, which are expected to provide significant supportive effect in suppression of proinflammatory reactions of the organism. Our method for differentiation between extra- and intracellular chemiluminescence will be applied for detection of neutrophil oxidative burst.
Duration: 9.9.2008 – 30.6.2011
In vitro hodnotenie prestupu kožou a účinnosti antioxidačných a UV fotoprotektívnych látok
Program: VEGA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2008 – 31.12.2010
Nové farmakologické prístupy ovplyvnenia reumatoidnej artritídy študované na modeli adjuvantnej artritídy
New pharmacological approaches affecting rheumatoid arthritis studied on adjuvant arthritis
Program: VEGA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Annotation: Rheumatoid arthritis is a chronic, systemic inflammatory disease. Administration of nonsteroidalanti-inflammatory drugs and disease modifying drugs to patients is associated with adverse effects. Safer therapies are therefore required. The sources for new drugs for mono- or combined therapy of arthritis could be not only synthetic but also of natural origin. Coenzyme Q10, new pyridoindoles ad natural polysaccharides,which intended to be studied in the model of adjuvant arthritis, are expected to provide an important contribution.Further the activity of plant extracts and their active compounds will be studied. Arthritis will be induced to Lewisrats by Mycobacterium butyricum in adjuvans . The animals will receive the substances tested repeatedly. Theparameters evaluating the effects of the substances tested on immune, endocrine, and oxidative processes will be analyzed to describe and characterize the development of adjuvant arthritis as well as the effect ofpharmacological treatments.
Duration: 1.1.2008 – 31.12.2010
POLOS – Molekulové mechanizmy pôsobenia nových liečiv ovplyvňujúcich oxidačný stres – významný etiopatogenetický faktor početných chorôb
Molecular mechanisms of new drugs influencing oxidative stress – important ethiopathogenetic factor of numerous diseases
Program: SRDA
Project leader: Prof. MUDr. Bauer Viktor, DrSc.
Annotation: The project is aimed at understanding the mechanism of action of compounds with antioxidative and antiradical properties in tissue inflammation, ischemia/reperfusion, trauma, and chronic hyperglycemia, studied at preclinical level. It is supposed that the drugs may be used in inhibition of tissue oxidative impairment in stroke, neurotrauma, late consequences of diabetes, rheumatoid arthritis, myocardial infarction, etc. The outcome of the targeted analysis will be the suggestion of strategies in therapy, only rarely used in contemporary medicine. New knowledge on pharmacology of compounds interfering with oxidative stress (OS) will contribute to their use in combined prevention and therapy („the multibulletted concept“) of diseases in which OS is participating. The project will contribute to broadening the array of suitable medicines by new drugs with satisfactorily understood mechanism of action and will provide the rationale of pharmacologic intervention based on reduction of OS in tissues.
Duration: 1.9.2006 – 31.10.2009
Vplyv imunostimulátorov a ich kombinácie s metotrexátom na adjuvantnú artritídu u potkanov
Effect of immunostimulators and their combination with methotrexate on adjuvant arthrithis in rats
Program: SRDA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Annotation: Rheumatoid arthritis in humans has been accompanied by chronic activation of the immune system, development of oxidative stress and immunoendocrine dysballance. The mechanisms of these processes will be followed on adjuvant arthritis in rats (AA). The aim of the submitted project is to study: 1) Prophylactic effects of methotrexate, or substances such as immunomodulators on the course of AA, 2) Combinations of these substances with the aim to find the most favorable combination at lowest doses with potential synergic effect. The most effective combination will be used also in therapeutic regiment. We will follow inflammatory and arthritic parameters, parameters of oxidative stress, cytokine and hormone levels. The results will show new possibilities for combined therapy which can be potentially used in the treatment of human rheumatoid arthritis with reduced adverse side effect often seen in monotherapies.
Duration: 1.5.2006 – 30.4.2009
Špecifické antagonisty znižujúce produkciu proinflamatórnych cytokín (MVP),proliferáciu a patologickú remodeláciu po infarkte myokardu (IM) a pri chronickom zlyhaní srdca(CHZ)
Specific antagonists myocardial production and secretion of p roinflammatory cytokines(IC), expression of mitogenic vasopressor peptides (MP), polyferation and pathological remodelation after myocardial infarction (MI) and in chroni heart failure (CHF)
Program: VEGA
Project leader: MUDr. Dřímal Ján, DrSc.
Duration: 1.1.2005 – 1.12.2007
Účinky antioxidantov a látok ovplyvňujúcich imunitný systém študované in vivo na modeli adjuvantnej artritídy
Effects of antioxidants and substances afecting the imunita systém studied in vivo using a model of adjuvant arthritis
Program: VEGA
Project leader: PharmDr. Bauerová Katarína, PhD., DrSc.
Duration: 1.1.2005 – 1.12.2007