Previous Projects

Completed projects over the past five years.

International

An integrated European platform for pancreas cancer research: from basic science to clinical and public interventions for a rare disease
An integrated European platform for pancreas cancer research: from basic science to clinical and public interventions for a rare disease
Program: COST
Project leader: Ing. Ďurišová Mária DrSc.
Duration: 14.12.2012 – 13.12.2016
COST BM1204 – COST BM1204 : Integrovaná európska platforma pre výskum rakoviny pankreasu: od základného výskumu ku opatreniam v klinickej medicíne a verejnom zdravotníctve v oblasti zriedkavých chorôb
COST BM1204 : An integrated European platform for pancreas cancer research: from basic science to clinical and public health interventions for a rare disease
Program: COST
Project leader: RNDr. Májeková Magdaléna PhD.
Annotation: To present the method based on molecular modeling, which is connected with potential molecular target for pancreas cancer detection, treatment and prevention. The aldo-keto reductases (AKRs) are enzymes with beneficial physiological functions, but they can play also a negative role by various pathologic processes. Our aim is to elaborate models of AKR subtypes specific for pancreatic cancer, drug design and characterization of novel aldo-keto reductase inhibitors of indole type with potential therapeutic effect in relation to pancreatic cancer and to evaluate their use together with biochemical experiments.
Project web page: http://eupancreas.com
Duration: 16.7.2012 – 13.12.2016
Phytochemicals in ameliorating rheumatoid arthritis therapy: from preclinical studies to clinical applications
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína PhD., DrSc.
Duration: 1.1.2013 – 31.12.2015
Role of the systemic inflammatory processes in the development of oxidative stress in the brain of arthritic subjects. Evaluation of experimental therapy based on new carnosine preparations
Role of the systemic inflammatory processes in the development of oxidative stress in the brain of arthritic subjects. Evaluation of experimental therapy based on new carnosine preparations
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína PhD., DrSc.
Duration: 1.1.2013 – 31.12.2015
The characterization and functional effects of quercetin and its derivative CHNQ, a potent aldo keto reductase inhibitor, in colorectal cancer
The characterization and functional effects of quercetin and its derivative CHNQ, a potent aldo keto reductase inhibitor, in colorectal cancer
Program: Bilateral – other
Project leader: Ing. Štefek Milan CSc.
Duration: 1.1.2013 – 31.12.2015
GLIADIN – Výskum a vývoj špecifických protilátok voči rôznym typom gliadínových fragmentov a štúdium vplyvu potravy a imunizácie na afinitu týchto protilátok
Program: Bilateral – other
Project leader: RNDr. Gajdošíková Alena
Annotation:
Duration: 1.1.2012 – 31.12.2015
COST CM1103 Štrukturálne podmienené navrhovanie liečiv na diagnózu a liečenie neurologických ochorení
COST CM1103 Structure-based drug design for diagnosis and treatment of neurological diseases
Program: COST
Project leader: RNDr. Májeková Magdaléna PhD.
Duration: 28.11.2011 – 27.11.2015
Chémia neenzymatických proteínových zmien – modulácia proteínovej štruktúry a funkcie
Chemistry of non-enzymatic protein modification – modulation of protein structure and function
Program: COST
Project leader: RNDr. Horáková Ľubica PhD.
Duration: 1.11.2010 – 31.10.2014
Fetegovanie evolučných "hot spots" rezistencie antibiotík v Európe
Detecting evolutionary hot spots of antibiotic resistances in Europe
Program: COST
Project leader: Ing. Ďurišová Mária DrSc.
Annotation: The main objective of DARE is to identify and characterize environmental hot spots for antimicrobial resistance emergence and spreading of antibiotics and antibiotic resistance patterns, aiming at the development of measures to control antibiotic resistance evolution.
Duration: 23.9.2009 – 22.9.2013
Nové pokroky vo výskume histamínového H4R receptora
Recent advances in histamine receptor H4R research
Program: COST
Project leader: prof. MUDr. Nosáľ Radomír DrSc.
Annotation: COST Action BM0806 is a broad research group with multidisciplinary approach focusing on the research of H4 histamine receptor. The H4 histamine receptor is known from the year 2000 and it is likely to be involved in hematopoiesis, immune cells regulation or inflammation. Pre-clinical data suggest involvement of H4 histamine receptors and their agonists/antagonists in regulation of allergy, inflammation, autoimmune diseases and cancer.The Action COST BM0806 comprises 4 different groups:1/ Methodological approaches for H4R systems investigation2/ (Patho)physiological importance of H4R systems3/ Pharmacological properties of new selective H4R ligands4/ Therapeutic potential of new H4R histaminergic compounds.We are investigating the involvement of histamine H4 receptor agonists and antagonists in the regulation of activated human neutrophils (working group 2).
Duration: 9.4.2009 – 8.4.2013
In vitro and in vivo models of arthritic processes for studying the mechanisms of inflammation and oxidative stress link-up. New perspectives for arthritis therapy
In vitro and in vivo models of arthritic processes for studying the mechanisms of inflammation and oxidative stress link-up. New perspectives for arthritis therapy
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína PhD., DrSc.
Duration: 1.1.2010 – 31.12.2012
Regulation of cytokine synthesis during inflammation develoment in brain and other tissues
Regulation of cytokine synthesis during inflammation develoment in brain and other tissues
Program: Bilateral – other
Project leader: PharmDr. Bauerová Katarína PhD., DrSc.
Duration: 1.1.2010 – 31.12.2012
2 VPH NoE – Virtuálna fyziológia človeka
Virtual Physiological Human, Network of Excellence, 7FP WU
Program: FP7
Project leader: Ing. Ďurišová Mária DrSc.
Annotation: A study, mathematical modeling, and simulations of physiological processes on whole-body, tissue, and cellular level under physiological conditions and also under pathological conditions. A study of possible pharmacological influences of studied processes under pathological conditions.
Project web page: http://www.vph-noe.eu/
Duration: 1.5.2009 – 31.12.2012

National

Epikatechín v prevencii včasného rozvoja primárnej hypertenzie: mechanizmy pôsobenia v kardiovaskulárnom a centrálnom nervovom systéme
Program: VEGA
Project leader: RNDr. Sotníková Ružena CSc.
Duration: 1.1.2014 – 31.12.2016
MVTS Integrovaná európska platforma pre výskum rakoviny pankreasu: od základného výskumu ku opatreniam v klinickej medicíne a verejnom zdravotníctve v oblasti zriedkavých chorôb
MVTS An integrated European platform for pancreas cancer research: from basic science to clinical and public health interventions for a rare disease
Program: Other projects
Project leader: RNDr. Májeková Magdaléna PhD.
Annotation: To present the method based on molecular modeling, which is connected with potential molecular target for pancreas cancer detection, treatment and prevention. The aldo-keto reductases (AKRs) are enzymes with beneficial physiological functions, but they can play also a negative role by various pathologic processes. Our aim is to elaborate models of AKR subtypes specific for pancreatic cancer, drug design and characterization of novel aldo-keto reductase inhibitors of indole type with potential therapeutic effect in relation to pancreatic cancer and to evaluate their use together with biochemical experiments.
Project web page: http://www.cost.eu/domains_actions/bmbs/Actions/BM1204
Duration: 1.6.2013 – 13.12.2016
Farmakologická regulácia aktivity a apoptózy fagocytov: štúdium na celulárnej a molekulárnej úrovni
Pharmacological regulation of phagocyte activity and apoptosis: studies on cellular and molecular levels
Program: VEGA
Project leader: RNDr. Drábiková Katarína PhD.
Duration: 1.1.2013 – 31.12.2015
Kvasinky a ich možnosti pri ochrane integrity medzibunkových spojení vaskulárneho endotelu pred poškodením vyvolaným zápalom
Yeasts in protection of endothelial intercellular connections against inflammation-induced injury
Program: VEGA
Project leader: RNDr. Sotníková Ružena CSc.
Duration: 1.1.2013 – 31.12.2015
Prenatálne programovanie psychiatrických porúch: experimentálne možnosti hodnotenia mechanizmov vzniku psychiatrických porúch na animálnych modeloch
Prenatal programming of psychiatric diseases: experimental approaches for evaluation of causes and mechanisms of their origin
Program: VEGA
Project leader: RNDr. Mach Mojmír PhD.
Annotation: Incidence of mental diseases in the developed countries has an increasing trend. At least one mental disease occurred per year approximately in 27% of EU inhabitants (more than 82 mil. people). It is estimated that till 2020, depression will be the main cause of morbidity in the developed countries. There are many evidences on neurodevelopmental origin of mental diseases. Various environmental and maternal factors acting during prenatal period and early childhood can increase sensitivity of the individual to anxiety, depression or other mental disorders in later postnatal life. Insufficient oxygen and nutrition supply of tissues, excessive stress or chemical substances and drugs can adversely affect the development of the brain. Objective of the project proposal will be the evaluation of key epigenetic factors which may play an important role in development of mental diseases.Up-to-date molecular biology as well as non-invasive methods of ethological analyses of appropriate animal models will be utilized.
Duration: 1.1.2012 – 31.12.2015
Starnutie mozgu a neuroprotektívne antioxidanty: Ovplyvnenie glií ako terapeutická stratégia?
Program: VEGA
Project leader: Ing. Račková Lucia PhD.
Duration: 1.1.2012 – 31.12.2015
Zlyhanie mozgového energetického metabolizmu v patobiochemickom mechanizme hypoxicko-ischemického poškodenia mozgu novorodencov
Cerebral energy metabolism failure as one of patho-biochemical mechanisms involved in hypoxic-ischemic insult of the neonatal brain
Program: VEGA
Project leader: RNDr. Juránek Ivo PhD., DrSc.
Annotation: The main purpose of the project is to contribute for elucidation of mechanisms of hypoxic-ischemic damage (HID) of the neonatal brain, which is cause of ~50% of newborn deaths. Survived infants often suffer from chronic neuro-psychiatric disorders (e.g. cerebral palsy, epilepsy, cognitive and behavioral disorders). Secondary energy failure (SEF) is likely to play a key role in the evolving HID. In our previous studies, we found that primary energy failure (PEF) in the brain of newborn rats is proportional to the maturity of brain energy metabolism. Since SEF determines the severity of brain HID, our goals for the present project are: 1) to monitor HID of the neonatal rat brain; 2) to determine the time interval between PEF and SEF, as we propose its usage for an effective therapy; 3) to affect pharmacologically SEF. We expect that the inhibition of SEF should alleviate the process of brain HIP. We shall utilize biochemical, molecular-biological and, in particular, non-invasive MR approaches.
Duration: 1.1.2012 – 31.12.2015
CM1103 Štrukturálne podmienené navrhovanie liečiv na diagnózu a liečenie neurologických ochorení
CM1103 Structure-based drug design for diagnosis and treatment of neurological diseases
Program: Other projects
Project leader: RNDr. Májeková Magdaléna PhD.
Annotation: Based on our knowledge in design and modeling of indole compounds with neuroprotective effect and inhibition effect towards aldo-keto reductases we plan to use a multi-target potential of these compounds for the problems studied in the project COST CM1103. Our aims are:1) To elaborate molecule models for individual types of aldo-keto reductases (AKRs) important for neurological diseases.2) To suggest AKR inhibitors with indolic structure with optimal efficiency and bioavailability.3) To test new compounds as the inhibitors of enzymes important for monoamines metabolism.4) Structure-activity study.5) To test other effects of our compounds on an in vitro level in the framework of COST CM1103 collaboration.
Duration: 1.1.2014 – 27.11.2015
Modulácia kalciových púmp na úrovni sarkoplazmatického retikula (SR). Erytrocytov (RBCs) a pankreatických beta-buniek vo vzťahu k diabetu
Program: VEGA
Project leader: RNDr. Horáková Ľubica PhD.
Duration: 1.1.2011 – 31.12.2014
Molekulové modelovaníe, syntéza a biologická aktivita substituovaných pyridoindolov ako bifunkčných agens v prevencii diabetických komplikácií
Molecular modeling, synthesis and biological activity of substituted pyridoindoles as bifunctional agents in prevention of diabetic complications
Program: VEGA
Project leader: Ing. Štefek Milan CSc.
Duration: 1.1.2011 – 31.12.2014
Štúdium kombinácie imunosupresívnej liečby a ovplyvnenia redoxnej rovnováhy organizmu na zvieracích modeloch reumatoidnej artritídy
Study of combination of immunosuppressive treatment and substances affecting redox balance of organism on animal models of rheumatoid arthritis
Program: VEGA
Project leader: PharmDr. Bauerová Katarína PhD., DrSc.
Annotation: The focus of the project will be the study of the therapeutic potential of the substances with anti-oxidative properties within RA therapy, and in particular of MTX combined therapy. The adjuvant arthritis (AA) model will be used in Lewis rats. AA progress and its pharmacological influencing will be characterized by parameters expressing immunological, oxidative, and inflammatory processes. The chronic AA model will be supplemented by the model of inflammation induced by carrageenan, as well as by the study of substances evaluated in macrophage cell culture.For potential utilization in combined RA therapy, the following substances will be evaluated: carnosine and its acetyled derivative, natural polysaccharides, low-molecular antioxidants with thiol groups, herbal antioxidants, and anti-inflammatory antihistaminics. Evaluation in vivo of the aforementioned substances will take place after the in vitro analysis of the anti-oxidative efficiency in two independent models
Duration: 1.1.2011 – 31.12.2014
Štúdium pôsobenia reaktívnych foriem kyslíka a dusíka na vysokomolekulový hyalurónan, synoviocyty a chondrocyty
Study of Actions of the Reactive Oxygen/Nitrogen Species on High-Molar-Mass Hyaluronan, Synoviocytes, and Chondrocytes
Program: VEGA
Project leader: Ing. Šoltés Ladislav DrSc.
Annotation: Hyaluronan (HA) is a polysaccharidic constituent of numerous tissues in the vertebrate organisms. One ml of synovial fluid (SF) – an essential joint component – contains 2-3 mg HA, which molar mass reaches in healthy adults the magnitude of about several megaDaltons. However, at the inflammatory joint disorders, the mean molar mass of HA is significantly decreased. This decrease is accompanied by a pronounced decline of the HA solution viscoelasticity and loss of the lubricating properties of SF.Low resistance of HA against the action of oxidative species – free radicals, anions – stimulated our efforts to use this biopolymer as a relevant (endogenic) substance for in vitro investigations of the “damaging” action of oxidants and/or for evaluation of the efficacy of various compounds/drugs to act as scavenging antioxidants.The substances, which will have significant antioxidant effect against HA degradation will be tested in relation to their protective effect against damage of joint elements.
Duration: 1.1.2011 – 31.12.2014
Účinok pyridoindolových derivátov v podmienkach experimentálneho modelu neurodegenerácie
Effect of pyridoindole derivatives under conditions of the experimental model of neurodegeneration
Program: VEGA
Project leader: RNDr. Gáspárová Zdenka PhD.
Annotation: Stroke and brain ischemia occur more frequently in the aging population. In our last project we studied consequences of acute ischemic brain injury and the effect of pyridoindoles related to age. The aim of this project is to study the effect of pyridoindoles in the model of neurodegeneration induced by trimethyltin. Neurodegeneration is associated with oxidative injury and inflammation of CNS. Functional and morphologicalchanges, loss of neurons, activated microglia, increased level of pro-inflammatory compounds and markers of oxidative stress are associated with many diseases, as Alzheimer´s and Parkinson´s disease, multiple sclerosis, etc. Neurodegeneration is connected with memory trace injury and it aggravates the action to other stressors, e.g.ischemic brain injury. The aim of the new project is to study the effect of pyridoindole antioxidants with the prospect of using them in slowing down the progress of pathological events accompanied with neurodegenerative changes in CNS.
Duration: 1.1.2011 – 31.12.2014
MVTS: Chémia neenzymatických modifikácii proteínov – modulácia proteínovej štruktúry a funkcie.
Program: Other projects
Project leader: RNDr. Horáková Ľubica PhD.
Annotation:
Duration: 1.11.2010 – 1.11.2014
Molekulárne princípy ovplyvnenia aktivity a apoptózy fagocytov. Príspevok k novej stratégii farmakologickej modulácie zápalových procesov
Molecular principles of regulation of phagocyte activity and apoptosis. Contribution to new pharmacological strategy for modulation of inflammatory processes
Program: SRDA
Project leader: prof. MUDr. Nosáľ Radomír DrSc.
Annotation: The submitted project is a continuation of our previous successful programmes (APVV-51-0296/02, APVV-0315-07, VEGA 2/7019/27), which resulted in significant, published and cited results in the area of pharmacological modulation of mechanisms involved in inflammatory processes. We intend to analyse drugs, potential drugs and synthetic derivatives of natural substances with respect to their effects on selected parameters of phagocyte activity (formation of reactive oxygen and nitrogen species, phagocytosis, expression of surface glycoproteins) and apoptosis (externalisation of phosphatidylserine, propidium iodide intercalation, caspase-3 activity). Moreover, we will concentrate on several regulatory mechanisms (activation of protein kinase C, alterations in intracellular calcium concentration) and the in vivo effectiveness of the compounds tested will be studied under conditions of experimental arthritis. The scientific goal of the project is to obtain new information about effects of the compounds tested at different levels – from the molecular and cellular up to the whole organism. Original data expected to be acquired concern pharmacological regulation of phagocyte activity and apoptosis. These results may contribute to the formation of new strategies in the therapy of chronic inflammatory diseases with focus on the support of natural antiinflammatory mechanisms and the resolution of inflammation.
Duration: 1.5.2011 – 31.10.2014
Pohlavné rozdiely v etiopatogenéze kardiovaskulárnych a behaviorálnych porúch v dôsledku sociálnych stresov u jedincov s predispozíciou k hypertenzii
Program: SRDA
Project leader: RNDr. Sotníková Ružena CSc.
Duration: 1.5.2011 – 31.10.2014
Štúdium mechanizmov a možností skorej detekcie embryofetálneho poškodenia v dôsledku intrautreinnej a perinatálnej hypoxie
The study of mechanisms and possible early detection of embryofetal damage caused by intrauterine perinatal hypoxia
Program: VEGA
Project leader: Doc. RNDr. Ujházy Eduard CSc.
Annotation: Unfavorable conditions for intrauterine development represent foundation for health disturbances and morbidity after birth and in later life. For the proper diagnosis and reduction of hypoxia/ischemia (H/I) consequences it is essential to identify basic mechanisms and markers of H/I. Experimental approaches are important for the basic research. Chronic intrauterine hypoxia and acute perinatal hypoxia in rats belong to animal models appropriate for study H/I during sensitive stages of development. The aim of the project will be the sceening and evaluation of the indicators of H/I damage in mothers and fetuses during perinatal period. We will focus on observation of the structural and functional changes after H/I insult and finding suitable biomarkers of H/I in blood and urine samples. Integral part of this project will be correlations of given data from experimental studies with clinical observations in full-term asphyxiated newborns.
Duration: 1.1.2011 – 31.10.2014
Výskum technológií príprav disperzných koloidných sústav s multifunkčným efektom s realizáciou v liečebnej kozmetike
Program: SRDA
Project leader: Ing. Šoltés Ladislav DrSc.
Duration: 1.5.2011 – 31.10.2014
Vývinová neurotoxicita venlafaxínu: experimentálna štúdia neurobehaviorálneho vývinu a neuroendokrinných odpovedí
Program: VEGA
Project leader: RNDr. Dubovický Michal CSc.
Duration: 1.1.2011 – 31.10.2014
Socálny stres ako rizikový faktor včasného rozvoja hypertenzie u predisponovaných jedincov
Gender differences in etiopathogenesis of social stress-related cardiovascular and behavioral disorders in individuals with predisposition to hypertension
Program: VEGA
Project leader: RNDr. Sotníková Ružena CSc.
Duration: 1.1.2010 – 31.12.2013
Substituované pyridoindoly ako potenciálne látky s „multi-target“ účinkom v prevencii a liečbe niektorých chronických ochorení – teoretický screening
Substituted pyridoindoles as potential multi-target-directed ligands in prevention and treatment of chronic diseases – theoretical screening
Program: VEGA
Project leader: RNDr. Májeková Magdaléna PhD.
Annotation: Substituted pyridoindoles proved to be agents efficient in many processes involved in development and progressof various chronic diseases as diabetes mellitus, neurodegenerative diseases and other disorders. In agreementwith recent conception a compound capable of multi-target action in the framework of one or similar diseasesturns to be better drug candidate as single-target ligand. One of the latest compounds of this type, dimebolin, isknown with its antihistamine effects and recently it is getting to a clinical praxis as a drug slowing impacts ofAlzheimer and Huntington diseases. We plan to choose a representative sample of number 6-8 derivatives fromthe amount of almost one hundred pyridoindoles derivatives designed and synthesized in our Institute. Thederivatives chosen will be compared with reference compounds as to the calculated parameters factoring anantioxidant activity, a conformational flexibility and inhibition activities towards enzymes chosen from the ProteinData Bank.
Duration: 1.1.2011 – 31.12.2013
CEG – Centrum excelentnosti pre glykomiku
Centre of excellence for glycomics
Program: Štrukturálne fondy EÚ Bratislavský kraj
Project leader: Ing. Brnoliaková Zuzana PhD.
Annotation: The research of abnormnal glycosylation of proteins related to human diseases symptomatics is highly attractive nowadays. Within Slovakia, this research field oriented on biosythesis and biological functions of biomacromolecules is strictly limited: escpecially in case of separational and structural methodical issues as well as in case of computational technologies availability. The goal of this project is to create Centre of Excellence for Glycomics (CEG) to provide inevitable technical and methodical equipment to study biological functions of glycoproteins in living organisms. The information gained might be applied in clinical medicine and pharmacology. The potential of new glyco-markers and the development of new generation of glyco-therapeutics might contribute to the treatment of various hereditary and/or civilization diseases.
Duration: 1.10.2010 – 31.10.2013
Hodnotenie prírodných látok a ich výber pre prevenciu a liečbu civilizačných ochorení
Program: Štrukturálne fondy EÚ Bratislavský kraj
Project leader: RNDr. Horáková Ľubica PhD.
Annotation:
Duration: 1.6.2010 – 31.5.2013
Celulárne a funkčné aspekty farmakologickej modulácie aktivity proteínkinázy C
Molecular and functional aspects of the pharmacological modulation of protein kinase C activity
Program: VEGA
Project leader: prof. MUDr. Nosáľ Radomír DrSc.
Annotation: The project is focused on the analysis of cellular and molecular mechanisms participating in the pharmacological regulation of neutrophil activity. We shall concentrate our studies on the modulation of protein kinase C activity in relation to altered oxidative burst and apoptosis of neutrophils. Natural polyphenols – newly synthetised derivatives of stilbene, flavonoids and coumarins will be studied as potential regulators of neutrophil activity and as inhibitors of protein kinase C activity in enzyme and cell models. Biological effects of polyphenols will be compared with their structure parameters. We expect to acquire relevant information about regulation of neutrophil activity by natural compounds, which might be useful in the therapy of diseases connected with chronic inflammation.
Duration: 1.1.2010 – 31.12.2012
ROSK-QSAR – In silico, in vitro a ex vivo výskum vybraných antiinfekčných látok
IN SILICO, IN VITRO AND EX VIVO RESEARCH CONCERNING ANTI-INFECTIVE COMPOUNDS
Program: SRDA
Project leader: RNDr. Májeková Magdaléna PhD.
Annotation: As a result of the researches performed as part of the Romanian Project PNII- Partnerships in priority domains, contract no.41-055/2007 “Multidisciplinary research concerning synthesis, physico-chemical characterization and antimicrobial evaluation for new sulfones with dibenzothiepine structure” an original series of new dibenzothiepine sulfones was obtained, which exhibited antimicrobial and antifungal properties. Present Romanian- Slovak partnership intends to contribute to the effort to obtain new compounds as anti-infective active agents, which could respond to the current global requirements. We propose the rational synthesis of new dibenzothiepine anti-infective agents identified by theoretical calculus and by correlation with experimental determinations as having optimum activity, and a better pharmacokinetics.The project relies on the experience of the Romanian researchers (University of Medicine and Pharmacy, Faculty of Pharmacy, Bucharest) in drug synthesis, biopharmaceutical and pharmacokinetic studies and also relies on the experience of the Slovak researchers (Institute of Experimental Pharmacology & Toxicology, Bratislava) in the field of quantum- chemistry, molecular modelling, Quantitative Structure –Activity Releationships (QSAR).
Duration: 1.1.2011 – 31.12.2012
Molekulárno-biologické aspekty farmakologického ovplyvnenia aktivácie profesionálnych fagocytov
Program: SRDA
Project leader: prof. MUDr. Nosáľ Radomír DrSc.
Duration: 1.1.2010 – 31.12.2012
TransTox – Transfer poznatkov a technológií z výskumu a vývoja v toxikológii na hodnotenie environmentálneho a zdravotného rizika
Program: Štrukturálne fondy EÚ Bratislavský kraj
Project leader: prof. MUDr. Nosáľ Radomír DrSc.
Annotation:
Duration: 1.1.2010 – 30.6.2012