Current Projects

International

EU-CARDIOPROTECT – Realizácia terapeutického potenciálu nových kardioprotektívnych terapií
Realising the therapeutic potential of novel cardioprotective therapies
Program: COST
Project leader: MUDr. Ravingerová Táňa DrSc., FIACS
Annotation: The proposed COST Action will set up a pan-European Research Network of leading experts in cardioprotection, to jointly develop new initiatives and new strategies for finding innovative and more effective approaches to cardioprotection and for optimizing the pre-clinical and clinical evaluation of new cardioprotective therapies, so as to improve their translation into the clinical setting for patient benefit. The COST Action will co-ordinate and strengthen European research in the field of cardioprotection and accelerate scientific progress through the dissemination and sharing of new therapeutic targets, among network members and industrial partners, thereby facilitating the discovery of new cardioprotective therapies. By utilizing the joint expertise of different European network members we will investigate factors which confound the efficacy of new cardioprotection therapies including comorbidities (such as age, diabetes, and hypertension) and co-medications (such as anti-platelet therapies, statins and beta-blockers). Finally, we will set up a European network of research centers for multi-center laboratory testing of new cardioprotective therapies using small and large animal models of acute IRI in order to select those therapies most likely to succeed in the clinical setting. All aspects of this COST Action proposal require a critical mass of partners across a wide geographic distribution across Europe in order to deliver the objectives outlined in this proposal. The discovery of novel signaling pathways and targets underlying cardioprotection both within and outside the cardiomyocyte (WG1 NEW TARGETS), and the testing of different combinations of cardioprotective therapy (WG2 COMBINATION THERAPY) requires investigators with different experience and expertise across Europe. The ability to test the effect of confounders of cardioprotection (WG3 CONFOUNDERS) requires the expertise of different partners in the different co-morbidities and testing of co-medications. Finally, the most important objective of this COST Action proposal, requires the setting up of a Europe-wide research network for (a) multicenter testing of novel cardioprotective therapies using small and large animal models (WG4 CONSORTIUM) and (b) testing of novel cardioprotective therapies in proof-of-concept clinical studies and optimization of multi-center clinical outcome cardioprotection studies. By definition this requires a critical mass of research partners distributed across Europe.
Duration: 19.10.2017 – 18.10.2021
MuTaLig – Viac-cieľový model pre inovatívnu identifikáciu látok v procese objavovania liečiv
Multi-target paradigm for innovative ligand identification in the drug discovery process
Program: COST
Project leader: RNDr. Májeková Magdaléna PhD.
Annotation: The aim of this COST Action is to join highly-qualified research teams working in disciplines around the field of medicinal chemistry, into a novel network devoted to the multi-target issue in drug discovery. The choice of this theme is related to its marked multidisciplinary character, which can ensure a strong interaction among all COST Action participants. Currently, an important and emerging issue in modern drug discovery is to design novel or identify existing bioactive compounds, endowed with the capability to interact selectively with two or more macromolecular targets, exerting their effects against certain therapeutic goals in a synergic fashion. This leading concept stimulated this COST Action focusing on novel ligands able to recognize selected multiple targets, to promote closer scientific links among European research groups involved in medicinal chemistry field at both academic and industrial level. The research competencies of the network will span around medicinal chemistry, from synthetic chemistry, natural products and biophysics to theoretical chemistry, molecular modelling and biological screening.
Project web page: http://www.mutalig.eu/
Duration: 4.12.2015 – 29.10.2019
GLUCOLIPOTOX – Ovplyvnenie molekulovych dráh glucolipotoxicity novým karboxymetylovaným merkaptotriazinoindolovým ihibítorom aldo-ketoreduktázy AKRlBl v diabete, zápale a vekom podmienenej neurodegeneráci
Targeting Molecular Pathways of Glucolipotoxicity by a Novel Carboxymethylated Mercaptotriazinoindole Inhibitor of Aldo-Keto Reductase AKR1B1 In Diabetes, Inflammation and Age-related Neurodegeneration
Program: Bilateral – other
Project leader: Ing. Štefek Milan CSc.
Duration: 1.5.2016 – 30.4.2019
Podnetné organické syntézy inšpirované prírodou: od chémie prírodných látok poobjav liečiv
Challenging organic synthesis inspired by nature – from natural products to drug discovery.
Program: COST
Project leader: RNDr. Horáková Ľubica PhD.
Annotation: Natural products (NP) have had a major impact on chemistry, chemical biology and drug discovery and have been part of medical remedies since ancient times. Nowadays, NP represent a unique source of leads for medicinal chemistry and drugs derived from NP have found widespread use for the treatment of cancer, cardiovascular diseases, bacterial and fungal infections. The general aim of this COST Action is to advance the field and to maintain the high level of expertise in NP chemistry within Europe by combining synthetic chemistry, computational chemistry, chemical biology, and pharmacology to find new lead structures of pharmaceutical relevance. Since chemistry plays a key role in addressing the industrial requirements for preclinical candidates in terms of physicochemical properties of NP and their analogues, this Action further aims to promote the translation between fundamental academic research and industrial drug discovery by means of NP chemistry.
Duration: 15.3.2015 – 14.3.2019
Mechanizmy poškodenia srdca radiáciou a možnosti medikamentóznej prevencie.
Mechanisms of radiation injury to the heart. Preventive drug treatment.
Program: Multilateral – other
Project leader: D.h.c., Prof., MUDr. Slezák Ján DrSc., FIACS
Duration: 1.1.2014 – 31.12.2018

National

RIDD – Výskum magnetických foriem železa v rozvoji kardiovaskulárnych chorôb a porúch správania
Research of magnetic forms of iron in development of cardiovascular diseases and behavioural disorders
Program: SRDA
Project leader: RNDr. Bernátová Iveta DrSc.
Annotation: This project proposal is focused on the investigation of the role of iron in development of cardiovascular and behavioural disorders, prevalence of which is increasing during aging. The aim of this project is to investigate theimpact of aging on the metabolism of biogenic iron and its magnetic properties in association with metabolic and functional alterations in the cardiovascular system and brain in rats with various genetic predispositions tohypertension. We will determine the molecular biological changes on the level of gene expression, their encoded proteins and the activities of the enzymes involved in the endogenous antioxidant protection, the regulation of nitric oxide production and cell death due to ferroptosis in course of aging. We will also investigate the impact ofexogenously administered iron in the form of the biocompatible ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on blood pressure regulation and function of the heart and blood vessels in conditions of normotension, chronically increased blood pressure and acute stress (i.e. acutely elevated blood pressure).Results achieved in this project will contribute to better understanding of the effects of the altered iron metabolism, magnetic forms of bodily iron, as well as iron in the form of USPIONs, on the cardiovascular andcentral nervous systems and to prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery or as the contrast materials for new imaging methods in medicine.
Project web page: http://www.bionanoiron.sav.sk
Duration: 1.7.2017 – 30.6.2021
Mechanizmy zahrnuté v endotelovej dysfunkcii indukovanej kyselinou močovou v závislosti od veku a genetickej predispozície k hypertenzii
Mechanisms involved in uric acid-induced endothelial dysfunction depending on the age and genetic predisposition to hypertension
Program: VEGA
Project leader: MUDr. RNDr. Púzserová Angelika PhD.
Annotation: Studies have shown a significant relationship between increased concentration of uric acid in the blood (hyperuricaemia) and cardiovascular diseases, including hypertension. But there is little information on the mechanisms by which uric acid can lead to end-organ damage. Hyperuricaemia combined with hypertension is associated with endothelial dysfunction. However, the mechanisms by which hyperuricaemia causes endothelial dysfunction are not clarified. This project aims to clarify the relationship of hyperuricaemia and hypertension, especially in terms of endothelial function. The aim is to bring new results highlighting the impact of elevated concentrations of uric acid on the endothelium, and to reveal the mechanisms involved in endothelial dysfunction in conductive and resistant arteries isolated from peri-pubertal and adult normotensive, prehypertensive and hypertensive rats. The results will contribute to the knowledge about pathophysiology of hyperuricaemia-induced endothelial dysfunction.
Duration: 1.1.2017 – 31.12.2020
Redoxná homeostáza, proteostáza a zápal ako potenciálne ciele pre ovplyvnenie starnutia a s ním spojených ochorení: Modulácia pomocou látok prírodného a syntetického pôvodu
Redox Homeostasis, Proteostasis and Inflammation as Potential Targets For Influencing Ageing and Age-Related Diseases: Modulation by the compounds of natural and synthetic origin
Program: VEGA
Project leader: Ing. Račková Lucia PhD.
Annotation: Ageing is a natural and inevitable phenomenon which is also the main risk factor for the serious diseases. Free-radical theory of ageing states that organisms age because cells accumulate free radical damage over time. These changes are significantly amplified by the decline in proteolytic capacity. Microglia, as the main immune effector cells of the CNS, undergo these alterations as well. This results in their chronic activation and increased risk of neurodegeneration. The aim of the project is to investigate the potential of compounds of natural and synthetic origin to up-regulate Nrf-2/Keap-1 signalling pathway (in particular, the activation of genes responsible for maintenance of redox homeostasis and proteostasis), also in view of their simultaneous down-regulation of NFkB in microglia. Subject of the project will be also investigation of postranslantional modifications in the regulatory mechanisms of proteolysis in microglial cells.
Duration: 1.1.2017 – 31.12.2020
Vlastnosti Na,K-ATPázy, jedného z kľúčových systémov pre udržiavanie koncentrácie sodíka v organizme, v podmienkach zaťaženia organizmu po ožiarení.
Properties of the Na,K-ATPase, representing one of the crucial systems in maintaining the sodium homeostasis in the organism, after irradiation.
Program: VEGA
Project leader: RNDr. Vrbjar Norbert CSc.
Annotation: The present project is oriented to obtain new data concerning the maintenance of intracellular homeostasis of sodium, representing one of the unavoidable factors for appropriate regulation of cellular viability, after application of radiotherapy. Using in vivo model (rat) we will investigate the influence of gamma irradiation on the cerebral and renal Na,K-ATPase which is one of the crucial systems in maintaining appropriate intracellular concentration of sodium ions. The data will contribute to elucidation of molecular background of processes involved inmaintaining the cell’s viability in kidney and in brain from the aspect of possible protection of the organism against deleterious side-effects of radiotherapy.
Duration: 1.1.2017 – 31.12.2020
Vplyv endogénnej hladiny oxidu dusnatého a sírovodíka na tlak krvi, pulzovú vlnu, funkciu a štruktúru cievnej steny
Program: VEGA
Project leader: RNDr. Kristek František DrSc.
Duration: 1.1.2017 – 31.12.2020
Vplyv ultra malých superparamagnetických nanočastíc železa na kardiovaskulárny systém potkana v podmienkach vysokého krvného tlaku
Effect of ultrasmall superparamagnetic iron oxide nanoparticles on the cardiovascular system of rats with high blood pressure
Program: VEGA
Project leader: RNDr. Bernátová Iveta DrSc.
Annotation: This project will investigate the effect of ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on function and structure of the arterial wall and the heart in rats with high blood pressure. We will investigate if acute stress and chronic high blood pressure can facilitate the USPIONs uptake in the arterial wall and heart, tomodify cardiovascular function, including blood pressure regulation and to induce metabolic disorders, oxidative damage and alterations of the Fe2+/Fe3+ ratio in the heart and vasculature. We will investigate if L-type ofvoltage-dependent calcium channels is involved in iron uptake after USPIONs treatment. Results achieved in this project will contribute to better understanding of USPIONs effects on the cardiovascular system in conditions ofacute stress and high blood pressure as well as on prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery.
Duration: 1.1.2017 – 31.12.2020
Výskum možností a rozvoj SQUID magnetometrie pre vybrané aplikácie v biomedicíne a materiálovom výskume
Research on possibilities and development of SQUID magnetometry for selected applications in biomedicine and material research
Program: VEGA
Project leader: RNDr. Bernátová Iveta DrSc.
Annotation: Project has an interdisciplinary character.The aim is to show the possibilities of use of the SQUID magnetometry in study of the actual processes in medicine, biology and material research:-in analysis of the properties and magnetic characterization of the nanoparticles and nanoliquids, especiallyultra-small superparamagnetic nanoparticles based on iron oxides (USPIONs)-in investigation of the influence of the USPIONs on the function and structure of the blood vessels and heart, on development of the oxidative damage and in study of processes of the USPIONs transport through cell membranes, blood vessels and organs of rats with normal and high blood pressure-in development of the procedures and methods of quantification of the magnetic substances content in thehuman and animal cell cultures and organs- in study and development of the aluminate glasses with photoluminescence properties and other applications.
Duration: 1.1.2017 – 31.12.2020
MEDMEX – Kompenzačné ochranné mechanizmy ako účinný nástroj voči zvýšenej energetickej deficiencii patologicky zaťaženého myokardu: Výhodná perspektíva v modernej experimentálnej kardioprotekcii.
Study of endogenous compensatory mechanisms effective against energy deficiency in pathologycally loaded myocardium: Innovative approaches in experimental cardioprotection.
Program: SRDA
Project leader: Ing. Ferko Miroslav PhD.
Annotation: Research on field of compensatory mechanisms appears to be promising method for endogenous protection inpathologically loaded myocardium under condition of increased energy demands. The project aims to contributeto the knowledge in the field of experimental cardiology and point to new, alternative cardioprotective proceduresagainst ischemia-reperfusion injury. It is necessary to study the protective signaling pathways, propose potentialcardiomarkers and identify positive functional changes observed at the level of cardiac mitochondria and heart itsself for comprehensive understanding of the onset and progression of mechanisms of endogenous myocardialprotection leading to effective compensation against energy deficiency in ischemia/reperfusion injury. Severalapproaches utilize processes of endogenous protection to achieve cardioprotection, such as ischemic andpharmacological preconditioning, clinically applicable „remote“ ischemic preconditioning (RIP) as well asexperimental streptozotocine-induced diabetes mellitus in acute state. Coexistence of several comorbidities (hypercholesterolaemia, hypertension) suppress mechanisms of cell signaling involved in protective effect ofischemic preconditioning that promotes necrotic and apoptotic processes in the myocytes during ischemiareperfusionchallenge and also reduces energy production. With respect to bioenergetics and the role ofmitochondria involved in the execution phase of cardioprotection as a common mechanism in various types ofadaptive phenomena, the information is scarse up to date. It is expected that the project will help to characterizethe changes caused by functional remodeling of the mitochondrial membrane, and provide a new and currentlyabsenting information on regulation of mechanisms against increased enegetic demands resulting in myocardialsurvival.
Duration: 1.7.2016 – 30.6.2020
DYSRPONEP – Dynamika srdcového poškodenia: úloha nekroptotickej bunkovej smrti a prežívania kardiomyocytov.
Dynamics of myocardial damage: a role of necroptotic cell death and survival of cardiomyocytes.
Program: SRDA
Project leader: MUDr. Ravingerová Táňa DrSc., FIACS
Annotation: Cardiomyocytes have a limited capability to proliferate, self-renew and repair. Therefore, the number of cardiac cells during postnatal development determines how the heart can deal with stress and workload demands. Both sudden acute or chronic progressive loss of heart cells are involved in the development of ventricular dysfunction and the progression of heart failure (HF). In cardiomyocyte loss, apoptosis seems to play a minor role comparedto necrosis. In line with this, we have found that markers of a newly described form of regulated necrosis – necroptosis are increased in human failing hearts whereas apoptotic ones are unchanged. Although it has been proposed that these markers form a cytotoxic complex, it is unclear how it induces necroptotic cell death. In this process, a protein RIP1 plays an important role. However, when it is polyubiquitinated it may trigger pro-survivalpathways instead. Stimuli, which preferentially trigger RIP1-mediated cell survival at the expense of cell death, are mostly unknown. In this project, we will study the cytotoxic action of necroptotic complexes with respect totranslocation into cell structures, disturbed ion homeostasis and oxidative stress. In addition, we will study whichRIP1-associated signaling is triggered during cell survival (eg. ischemic preconditioning – IPC) and which RIP1 pathways lead to the contrary, death of cardiac cells in acute myocardial infarction and during the development of HF of various origin. By using a necroptosis inhibitor, we will try to determine whether it affects IPC-induced cardioprotection with respect to cell viability and whether its time-dependent application can relieve remodeling and cardiac dysfunction due to myocardial infarction or induce regression of damage. Cardiomoycytes, isolated hearts and in vivo studies will be used to investigate signaling pathways and autocrine/paracrine and systemwide responses to a primary impulz that induces the damage/ adaptation of the heart.
Duration: 1.7.2016 – 30.6.2020
G-LUCK – Farmakologické ovplyvnenie glukózovej toxicity pri diabete typu 2
Pharmacological intervention in glucose-toxicity in type 2 diabetes
Program: SRDA
Project leader: RNDr. Májeková Magdaléna PhD.
Annotation: Glucose toxicity plays important role not only in a development of chronic diabetic complications but also in aninduction of insulin secretion disorder, decrease of beta cell mass and development of insulin resistance. Theaim of this project is to design and test novel compounds with indolyl acetic acid scaffold, multi-target-directedligands, which should slow down the onset of diabetes mellitus type 2 and reduce progression of diabeticcomplications.
Duration: 1.7.2016 – 30.6.2020
Molekulárno-farmakologické prístupy k inovatívnej terapii reumatoidnej artritídy hodnotenej v experimentálnych podmienkach in vivo a in vitro
Program: SRDA
Project leader: PharmDr. Bauerová Katarína PhD., DrSc.
Duration: 1.7.2016 – 30.6.2020
NO-NEW-REG – Nové regulačné účinky oxidu dusnatého a ich úloha v rozvoji esenciálnej hypertenzie
New regulatory effects of nitric oxide and their role in the development of essential hypertension
Program: SRDA
Project leader: RNDr. Čačányiová Soňa PhD.
Annotation: High blood pressure is a main risk factor in sustained increased morbidity and mortality of humans suffering cardiovascular diseases. Understanding of causes leading to hypertension enable to reveal new preventive andtherapeutic decisions. A new regulatory system involved in vessel tree regulation seems to be neuronal NOsynthase (nNOS) and its interactions with other regulatory systems. On the level of the kidney nNOS signal pathway interferes with renin-angiotensin system (RAS) and sulfide signalization (H2S), and the interactionsamong them are the unexplored area of regulatory mechanisms. nNOS in macula densa stimulate renin syntesis and via it influences RAS and sympathetic nerve system, on the other hand, H2S inhibits renin synthesis. Moreover, the regulatory pathways of nNOS and also endothelial eNOS could interact with endogenous NOSinhibitor, asymmetric dimetylarginine ADMA, on local as well as systemic level. The aim of the project is to study the effect of interactions of NO/nNOS/eNOS signalization with mentioned regulatory pathways (RAS, H2S,ADMA) on cardiovascular system and to find out their role in the specificity of nNOS and/or eNOS action in the conditions of essential hypertension. The availability of the results will be reached via using complex approach(functional, molecular, morphological). Moreover, on the level of acute experiments, we will confront selectedbiochemical markers of perivascular adipose tissue (plasma/serum) as well as vasoactive responses of arteriesisolated from normotensive and hypertensive rats with biochemical markers and reactivity of vessels isolated after nephrectomy from normotensive patients and patients with essential hypertension.
Duration: 1.7.2016 – 30.6.2020
SCAVRAD – Ochrana srdca v situáciách zvýšenej produkcie voľných kyslíkových radikálov: Radiačné a reperfúzne poškodenie.
Protection of the heart in situations of increased production of oxygen free radicals: Radiation and reperfusion injury.
Program: SRDA
Project leader: D.h.c., Prof., MUDr. Slezák Ján DrSc., FIACS
Annotation: According to statistics, cardiovascular and cancer are the main cause of more than 93% of the global morbidityand mortality.One of the most used methods to treat patients with cancer is radiotherapy, which uses ionizing radiation.Ionizing radiation damages the cancer cells, leading to their apoptosis and to potential patient recovery.However, during irradiation of cancer cells may also occur unintended exposure of surrounding healthy tissue,which in turn can cause serious health complications including radiation-induced heart disease. Ionising radiationacts directly on the DNA of cells, or indirectly through the formation of free radicals, which then damage theindividual organelles of cells or DNA. Production of oxygen free radicals, which in addition have a signalingfunction, at higher concentrations have toxic effects on all parts of the heart and blood vessels, is a commondenominator of both ionizing radiation and inflammation, as well as ischemic and reperfusion injury. Therefore,research in this field, and finding novel suitable materials which can positively influence the effects of over
Duration: 1.7.2016 – 30.6.2020
Prenatálne a postnatálne účinky ligandov δ a µ opioidných receptorov na vývoj a funkciu hipokampu
Prenatal and postnatal effects of δ and µ opioid receptor ligands on the hippocampal development and function
Program: SRDA
Project leader: RNDr. Dubovický Michal CSc.
Annotation: Ligands of opioid receptors δ (DOR) and µ opioid receptors (MOR) are commonly used in treatment of severe acute and chronic pain. DORs are involved also in mood disorders like depression and anxiety, which are related to the hippocampal function. Treatment with DOR ligands does not result in adverse effects including addiction, which are common with MOR ligands. However, much less is known about DOR – activated signaling pathways than about MOR – activated pathways. We will analyze the effect of acute (seconds to minutes) and chronic (hours to days) in in vitro and in vivo (prenatal and postnatal) administration of DOR ligands on the morphological and electrophysiological properties of rat hippocampal neurons and compare them with effects of MOR ligands and with effects of ligands specific for MOR-DOR heteromers. Further, involvement of calcium transporting proteins in signal transduction pathways activated by DORs and MORs ligands will be addressed by molecular biology methods. Possible remodeling of the dendritic spines will be investigated using transmission electron microscopy. Effect of DOR ligands on hippocampal plasticity in control and stressed rats will be examined using behavioral tests and molecular neuroscience techniques. Excitability will be investigated in primary culture of hippocampal neurons by patch clamp and in situ by in vivo electrophysiology. Both models enable to follow effects of acute and chronic drug application as well as possible receptor desensitization and offer complementary advantages. Primary neuronal culture is the possibility to visually identify neurons, characterize in details both action potentials and underlying ionic currents and to correlate electrophysiology and molecular biology on the same batch of neurons. In vivo electrophysiology offers the possibility to measure neuronal activity within its normal environment including all interactions with other brain parts.
Duration: 1.7.2016 – 30.6.2020
Štúdium anatomicko-funkčných rozdielov v účinkoch aripiprazolu a kvetiapínu, atypických antipsychotík s podobnými terapeutickými vlastnosťami, ale rozdielnym vplyvom na dopaminergické receptory v mozgu, u experimentálnych zvierat
Investigation of anatomical-functional differences between the effects of aripiprazole and quetiapine, atypical antipsychotics with similar therapeutic indications, but different impact on brain dopaminergic receptors, in experimental animals
Program: SRDA
Project leader: RNDr. Mach Mojmír PhD.
Annotation: Antipsychotics (APs) represent a group of drugs used in the treatment of spectrum of psychotic and depressive disorders. However, frequency of ATs treatment is rather increasing than decreasing and growing number of atypical AP drugs have also been emerged over the last few years. In addition, APs treatment is connected with a number of unwanted side effects, such as extrapyramidal syndrome, akathisia, body mass increase, agranulocytosis, tardive dyskinesia, somnolencia, etc. Anatomical-functional investigations are incessantly bringing information about the effects of APs on the activity of neurons and their spatial distribution in the brain, which allows more precisely to define and predict the consequences of the APs treatment. The aim of the present study is to reveal the effect of acute and repeated treatment of two, relatively new atypical APs, aripiprazole (ARI) and quetiapine (QUE), on the activity of neurons in the forebrain and extra forebrain areas of the brain, to identify the phenotype (chemical) character of the targeted neurons, to investigate their impact on the behavior and to compare their impact on the activity of signaling pathways, expression of signaling molecules, and secretion of selected neuropeptides in anatomically precisely defined brain structures. The data of the present project will be new and will serve for the deeper understanding of the biology of serious mental disorders. They also may bring new impulses to the drug developing processing to prepare drugs with more directed and beneficial therapeutic features.
Duration: 1.7.2016 – 30.6.2020
H2S-NO – Štúdium biologických účinkov produktov H2S/NO interakcie a molekulárne mechanizmy ich pôsobenia
Study of biological effects of H2S/NO products and molecular mechanism of their actions
Program: SRDA
Project leader: RNDr. Čačányiová Soňa PhD.
Annotation: Now it is well acknowledged that endogenously produced H2S affects and is involved in regulation of many physiological and pathological functions of living organisms. It is suggested that biological effects of H2S mightnot result from actions of H2S alone, but from its oxidation products, which come from e.g. interaction of H2S with NO. Last four years, our “international” group indentified the following products of H2S and NO interaction:nitrosopersulfide (SSNO−), polysulfides (HSn−) and dinitrososulfite [N-nitrosohydroxylamine-N-sulfonate (SULFI/NO) (Proc Natl Acad Sci U S A. 112, 2015, E4651-E4660). Biological effects and molecular mechanisms of these products are not completely understood Therefore the aim of our project is to explore biological effectsof the products of H2S/NO interactions and to study their molecular mechanism of their actions. Particularly, as a continuation of our research, we will study their effects on rat blood pressure and aortic rings relaxation. Toelucidate molecular mechanisms of their biological effects, we will study their influence on expression ofenzymes that endogenously produce H2S (CBS, CSE and 3-MST), on intracellular membrane channels,concentration of intracellular calcium, lipid peroxidation and their antioxidant properties. Goal of the project isalso to find out, if studied compounds could provide us with information leading to a drug design based on their molecular structure, what could be an object for next application studies and lead to implementation in medical praxis.
Duration: 1.7.2016 – 30.6.2020
Hypoxia ako prevencia zlyhávania srdca potkana a jej vplyv v rôznych fázach zlyhávania: Charakteristika funkčných, štrukturálnych a molekulárnych zmien.
Hypoxia in the prevention of heart failure in rats and its influence in various stages of heart failure: Characteristics of functional, structural and molecular changes.
Program: VEGA
Project leader: Mgr. Farkašová Veronika PhD
Duration: 1.1.2017 – 31.12.2019
Modulácia vápnikovej homeostázy flavonoidmi v pankreatických beta-bunkách za podmienok stresu endoplazmatického retikula
Modulation of calcium homeostasis in pancreatic beta-cells by flavonoids under conditions of endoplasmic reticulum stress
Program: VEGA
Project leader: RNDr. Lomenová Jana PhD.
Annotation: The project is aimed at the evaluation of protective effect of selected flavonoids and their derivatives upon injury to the pancreatic INS-1E ß-cells under conditions of ER stress in terms of reduction of apoptosis, regulation of intracellular calcium, decrease of intracellular ROS/RNS, increase of insulin secretion and regulation of the expression of the Ca2+ regulating proteins. Flavonoids will be selected based on molecular modeling (interaction SERCA – flavonoid) in silico and based on effects on SR/ER Ca2+-ATPase (SERCA) activity in vitro. Endoplasmic reticulum (ER) stress in pancreatic ß-cells will be induced by: i) free fatty acids, ii) cytokines iii) specific SERCA inhibitors such thapsigargin, iv) high glucose/methylglyoxal, v) reactive oxygen/nitrogen species (eg. peroxynitrite).Effect of flavonoids on ER stress will contribute to the understanding of the mechanism of action of these substances potentially useful in the prevention/treatment of type 2 diabetes and its complications.
Duration: 1.1.2016 – 31.12.2019
Ochrana mechanizmov modulujúcich permeabilitu endotelu v srdci.
Protection of mechanisms modulating endothelial permeability in the heart.
Program: VEGA
Project leader: RNDr. Okruhlicová Ľudmila CSc.
Duration: 1.1.2016 – 31.12.2019
Prenatálne programovanie chorôb v dospelosti: subchronická prenatálna asfyxia u potkanov ako vhodný model na štúdium mechanizmov embryo-fetálneho programovania neurobehaviorálnych zmien v dospelosti
Prenatal programming of psychiatric diseases: experimental approaches for evaluation of causes and mechanisms of their origin
Program: VEGA
Project leader: RNDr. Mach Mojmír PhD.
Annotation: Incidence of mental diseases in the developed countries has an increasing trend. At least one mental disease occurred per year approximately in 27% of EU inhabitants (more than 82 mil. people). It is estimated that till 2020, depression will be the main cause of morbidity in the developed countries. There are many evidences on neurodevelopmental origin of mental diseases. Various environmental and maternal factors acting during prenatal period and early childhood can increase sensitivity of the individual to anxiety, depression or other mental disorders in later postnatal life. Insufficient oxygen and nutrition supply of tissues, excessive stress or chemical substances and drugs can adversely affect the development of the brain. Objective of the project proposal will be the evaluation of key epigenetic factors which may play an important role in development of mental diseases.Up-to-date molecular biology as well as non-invasive methods of ethological analyses of appropriate animal models will be utilized.
Duration: 1.1.2016 – 31.12.2019
Prevencia hypoxicko-ischemického poškodenia neonatálneho mozgu potkana: testovanie nových spôsobov farmakologickej a nefarmakologickej intervencie
Prevention of hypoxic-ischemic damage of the neonatal rat brain: testing of novel approaches involving pharmacological and non-pharmacological intervention
Program: VEGA
Project leader: RNDr. Juránek Ivo PhD., DrSc.
Annotation: The proposed project is focused on testing novel ways, suggested by our group, to prevent neonatal brain damage resulting from perinatal hypoxic-ischemic (HI) insult, which is one of the most frequent causes ofnewborn mortality and morbidity. So far, there is no effective therapy for neonatal HI encephalopathy. In the present project, newborn rats will be exposed to cerebral HI insult, and brain damage will be followednoninvasively by magnetic-resonance imaging (MRI) and spectroscopy (MRS) in vivo, and neurological deficit by standard neurobehavioral tests. Originality lies in using combination of antiinflammatory omega-3 fatty acids (DHA+EPA) and excitotoxicity inhibitor (MgSO4) against HI damage. Originality is also a in non-pharmacological approach that include combination of mild hypothermia (34°C) and graded reoxygenation (8-12-16-21% O2). Expected results will contribute to better understanding of mechanisms of HI brain damage and to a proposal of effective management of neonates with HI brain insult.
Duration: 1.1.2016 – 31.12.2019
Relevancia nekroptózy v odumieraní myokardiálneho tkaniva v dôsledku rôznych typov poškodenia: vplyv na excitačno-kontrakčné prepojenie.
Program: VEGA
Project leader: Ing. Ferko Miroslav PhD.
Duration: 1.1.2016 – 31.12.2019
Skúmanie regulačných mechanizmov medzibunkovej komunikácie v srdci pre cielenú ochranu pred jeho funkčným zlyhaním.
Investigation of regulatory mechanisms of cardiac cell-cell communication for targeted protection from heart failure.
Program: VEGA
Project leader: RNDr. Tribulová Narcisa DrSc.
Annotation: Cardiac cell-to-cell communication via gap junction connexin (Cx) channels is essential for synchronised heart function. While disorders in expression, distribution and phosphorylation of Cx in of both human and animal heart diseases promote occurrence of malignant arrhythmias and heart failure. We hypothesize that targetedmodulation of Cx channel function by exogenous and endogenous compounds may be a promising approach to protect proper heart function. Aim of this project is to elucidate mechanisms implicated in regulation ofCx43-mediated cardiac cell-to-cell communication in healthy and diseased heart. Research findings should enhance knowledge of cardiologists in this field and challenge the realization of clinical trials supporting novel approaches in prevention and/or treatment of heart diseases to fight sudden cardiac death.
Duration: 1.1.2016 – 31.12.2019
ENDBIOM – Sledovanie kritických endogénnych biomarkerov a signálnych dráh v hypertenzii a pri kardiovaskulárnych ochoreniach
Study of critical endogenous biomarkers and signaling pathways in hypertension and cardiovascular diseases
Program: VEGA
Project leader: RNDr. Dovinová Ima PhD.
Annotation: Several endogenous factors and signaling pathways contribute to the development of cardiovascular diseases. Activation of the renin-angiotensin and aldosterone system (RAAS), deteriorated relaxation of vasoactive systems producing NO and H2S, as well as an imbalance of redox pathways producing reactive oxygen and nitrogen species (ROS a RNS). Hypertension is a major risk factors of cardiovascular diseases and leads to functional and structural alterations in blood vessel walls. The landmarks of developed hypertension are increased vasoconstriction regulated by RAAS, oxidative stress manifested in increased ROS and RNS, endothelial dysfunction (increased levels of assymetric dimethyl-arginine – ADMA – and homocystein) as well as cardiovascular remodeling (activation of metaloproteinases). Detection, monitoring, and regulation of the critical pathology markers can lead to a better management of hypertension- and metabolic syndrome-related diseases.
Duration: 1.1.2017 – 31.12.2019
Špecifické metódy a inovované postupy posudzovania výkonnosti športovcov a telesnej zdatnosti bežnej populácie
Specific methods and innovative procedures for assessing performance in athletes and physical fitness in the general population
Program: VEGA
Project leader: RNDr. Bzdúšková Diana PhD.
Annotation: The project will design specific tests and innovative methodological procedures for assessing performance inathletes and physical fitness in the general population. These will be based on analysis of performance inselected sports and age specificities of the general population. Methodology of measurement and data analysiswith the highest accuracy of motor abilities evaluation will be verified. Their ability to differentiate between andwithin groups differences will also be evaluated. Part of the project will be testing guidance scales on groups ofelite athletes of selected sports and large population of varied ages. This will provide a basis for testing protocolsand recommendations for utilization of novel diagnostic methods in practice. Such diagnostics taking into accountspecific conditions of particular sports and age specificities represent significant shift in obtaining relevantinformation on performance in athletes and physical fitness in the general population and their longitudinalchanges.
Duration: 1.1.2017 – 31.12.2019
Účinok STAT1 a ISG15 inhibítorov na biochemické a morfologické parametre pri experimentálnom infarkte myokardu
The effect of STAT1 and ISG15 inhibitors on biochemical and morphological parameters in experimental myocardial infarction
Program: VEGA
Project leader: RNDr. Cebová Martina PhD.
Annotation: Myocardial infarction (MI) remains a major cause of morbidity and mortality throughout the world. Atherosclerosis,chronic inflammation and metabolic diseases are the main causes of MI. Hypertension is the most serious riskfactors which worsen the prognosis of MI via induction of oxidative and inflammatory mediators. Chronic ischemialeads to irreversible myocardial damage. Reperfusion of myocardium may potentially save myocardial function,paradoxically, this process causes further damage of the myocardium and apoptosis of cardiomyocytes alongwith upregulation of STAT1 and ISG15. Thus, it is important to study different molecules which may block orrevers pathological processes in myocardial reperfusion injury following MI at different levels. Therefore, the aimof our study is to analyze the effects of STAT1 and ISG15 inhibitors on reperfusion injury in the experimentalmodel of MI (ischemia-reperfusion injury after STEMI revascularization) and determination of pathophysiologicalchanges in this process.
Duration: 1.1.2017 – 31.12.2019
Úloha extracelulárnych vezikúl v medziorgánovej komunikácii zahrnutej v kardioprotekcii na diaľku (remote conditioning).
The role of extracellular vesicles in inter-organ communication related to remote cardioprotection
Program: VEGA
Project leader: RNDr. Barteková Monika PhD.
Annotation: Inter-organ communication plays a crucial role in cardioprotection induced by an ischemic (or other) insult on remote organ to the heart, called remote ischemic preconditioning, or remote conditioning in general. Extracellular vesicles (EVs) are membrane-bound structures secreted by a wide range of mammalian cell types that can be secreted and specifically taken up by other cells. Since EVs contain a high concentration of RNAs and proteins, they are of a high interest as potential mediators of remote cardioprotection, and thus for inter-organ signal transfer mechanisms in general. Revealing the role of EVs in communication between different cells and organs as well as identifying substances transported by EVs to be potential mediators of cardioprotection as the main goal of the current project could lead to better understanding of remote cardioprotection and inter-organ communication in general, and rise up new potential targets of therapy of heart ischemia.
Duration: 1.1.2016 – 31.12.2019
Vplyv transkraniálnej stimulácie mozgu jednosmerným prúdom na senzorimotorické vrátkovanie u človeka
Vplyv transkraniálnej stimulácie mozgu jednosmerným prúdom na senzorimotorické vrátkovanie u človeka
Program: VEGA
Project leader: MUDr. Jagla Fedor CSc.
Annotation: The term sensorimotor gating refers to a basic inhibitory process, which prevents processing of and reacting to irrelevant stimuli so that resources can be allocated to salient aspects of the environment. Disrupted gating is considered to play a causal role in the development of psychosis in schizophrenia spectrum disorders. Prefrontal cortex (PFC) is involved in inhibitory control processes and its dysfunction is a hallmark of schizophrenia. Transcranial direct current stimulation stimulation (tDCS) can be used to increase or decrease excitability of neuronal tissue and is increasingly used to modulate human brain activity and cognitive processes. In this project, we will systematically explore in healthy adults the possibility to modulate sensorimotor gating by tDCS of the PFC, which has not been investigated so far. Our findings will bring important new knowledge on the brain mechanisms of sensorimotor gating, pathogenesis of mental disorders and possibilities of their treatment.
Duration: 1.1.2017 – 31.12.2019
Interakcia nitrergickej, neurotrofickej a endokrinnej signalizácie v etiopatogenéze schizofrénie
Interaction of nitrergic, neurotrophic and endocrine signaling in the etiopathogenesis of schizophrenia
Program: SRDA
Project leader: MUDr. Riečanský Igor PhD.
Annotation: Schizophrenia is a common and severe mental disorder but its pathogenesis is yet poorly understood. Susceptibility to schizophrenia is largely genetic but the genetic predisposition is determined in a complex network of interactions between multiple risk genes and environmental factors, resulting in disordered brain development and function. There is increasing evidence that chronic stress and dysregulation of several signaling pathways plays role in the neurodevelopmental impairment underlying schizophrenia. In this project, by adopting a multidisciplinary approach, we will address at several levels (genetic, neurobiological and behavioral) a candidate pathophysiological pathway, involving nitrergic, neurotrophic and stress signaling, which might be importantly involved in the disordered brain development in schizophrenia. A focus on schizophrenia endophenotypes will enable us to integrate findings from human subjects at genetic risk of the disorder with those from a rodent neurodevelopmental model of schizophrenia. This project will bring important new knowledge on the etiopathogenesis of this devastating disorder and potential novel strategies of its treatment.
Duration: 1.7.2015 – 30.6.2019
Návrh a implementácia metodiky pre rehabilitáciu pacientov s bolesťami chrbta s využitím zrakového biofeedbacku
Design and implementation of visual biofeedback for the rehabilitation of mobility deficiencies in patients with low back pain
Program: SRDA
Project leader: Ing. Hlavačka František CSc.
Annotation: The main goal of this project is to design, optimize and implement a specialized method for the improved rehabilitation of mobility deficiencies in patients suffering from low back pain (LBP). The system will be equipped with accurate inertial measuring units embedded with highly sensitive micro-electro-mechanical (MEMS) accelerometers and gyroscopes, as well as a force platform providing input signals that will be processed and displayed back to the patient (visual biofeedback). LBP is a worldwide health problem affecting people of all ages, with recurring symptoms. Based on positive long-term experiences with visual biofeedback, the project strives to design an effective rehabilitation program for the improvement of impaired trunk mobility during sitting, and also impaired balance control during stance in LBP patients. The project not only includes the accurate acquisition of postural data, but also the development of software which will process, interpret and display this data in an easy to understand way. The software is intended to be easily operated and include training tasks that can be personalized to patient specific requirements. The ultimate goal of the project is to implement complex sensor systems capable of accurate measurements but process the data into an easy to use and easy to interpret rehabilitation tool for improving postural and motor function deficiencies in patients suffering from LBP.
Duration: 1.7.2017 – 30.6.2019
NANOSIMKA – Účinok nanoenkapsulovaného simvastatínu na kardiovaskulárny systém pri experimentálnom metabolickom syndróme
Effects of nanoencapsulated simvastatin on cardiovascular system in experimental metabolic syndrome
Program: SRDA
Project leader: doc. RNDr. Pecháňová Oľga DrSc.
Duration: 1.7.2015 – 30.6.2019
MVTS: Podnetné organické syntézy inšpirované prírodou – od chémie prírodných produktov po objav liečiv
Program: Other projects
Project leader: RNDr. Horáková Ľubica PhD.
Duration: 1.3.2015 – 31.3.2019
Efekt lyofilizátu Cornus mas L. na kardiometabolické a zápalové parametre pri experimentálnom metabolickom syndróme
Effect of lyophylisate Cornus mas L. on cardiometabolic and inflammatory parameters in experimental metabolic syndrome
Program: VEGA
Project leader: Doc.MUDr. Lietava Ján CSc.
Duration: 1.1.2016 – 31.12.2018
Inhibícia proliferácie a indukcia apoptózy v rakovinových bunkách ovplyvnením ich metabolického profilu
Inhibition of proliferation and induction of apoptosis in cancer cells by affecting the metabolic profile
Program: VEGA
Project leader: RNDr. Blaškovič Dušan PhD.
Annotation: The aim of the project is to inhibit the growth and induce apoptosis in cancer cells by affecting the following metabolic pathways: glycolysis, Krebs cycle, the pentose phosphate cycle and fatty acid synthesis. Cancer cells HeLa ( cervix ) , HCT – 116 ( colon ) and MCF – 7 ( breast ) will be incubated with inhibitors of particular metabolic pathways to determine the pathway, which inhibition caused the greatest decrease of the growth, respectively the induction of apoptosis . The project is also aimed on the study of the effect of inhibiting of various metabolic pathways by natural substances, which are non-toxic for the normal cells. Multiple pathways will be simultaneously inhibited in cancer cells using natural substances to reach the most significant suppression of cancer cell growth and/or induction of apoptosis. Research will also focus on determation of the impact of coltsfoot extract on selected metabolic pathways and viability of cancer cells.
Duration: 1.1.2015 – 31.12.2018
Mechanizmy, skorá detekcia a terapia asfyktického poškodenia v perinatálnom období – porovnanie experimentálnych údajov s klinickým obrazom asfyktického novorodenca
Mechanisms, early detection and therapy of asphyxial injury in perinatal period – comparison of experimental data with clinical observation of asphyxial newborns
Program: VEGA
Project leader: Doc. RNDr. Ujházy Eduard CSc.
Annotation: The results from our studies concerning uncovering the mechanisms and possibilities of early detection of embryo-fetal damage confirmed that our proposed model of subchronic perinatal asphyxia using rat model is suitable for next studies. We will use this model for further expansion of knowledge about the mechanisms of actions of asphyxia in the process of late organogenesis and perinatal period. It is important to detect suitable biochemical and morphological markers to reduce the risk of complications due to asphyxia during development, as well as the possibility of its early therapy via antioxidant active ingredients of natural and synthetic origin. The ability of these compounds to bind to transport blood components (albumin, hemoglobin) will be monitored and a method for testing the effects on neuronal cell cultures will be developed. Integral part of this project will be correlations of given data from experimental studies with clinical observations in full-term asphyxiated newborns.
Duration: 1.1.2015 – 31.12.2018
Názov projektu: Výskum ovplyvnenia zápalu, chronickej autoimunitnej reakcie a redoxnej regulácie organizmu v experimentálnej artritíde použitím nových látok pre adjuvantnú terapiu reumatoidnej artritídy
Program: VEGA
Project leader: PharmDr. Bauerová Katarína PhD., DrSc.
Duration: 1.1.2015 – 31.12.2018
Ochrana srdca pred maladaptívnou remodeláciou extracelularnej matrix a skúmanie mechanizmov jej regresie.
Protection of the heart from maladaptive extracellular matrix remodeling and searching the mechanisms of its regression.
Program: VEGA
Project leader: RNDr. Szeiffová Bačová Barbara PhD.
Annotation: Heart diseases are accompanied by exracellular matrix remodeling and fibrosis resulting in development of heartfailure and malignant arrhythmias. Fibrosis is a major medical problem without existing cure. However, there arecardioprotective compounds that exhibit antifibrotic effects but underlying mechanisms are poorly understood.This project is aimed to characterize key factors implicated in profibrotic signaling in rats suffering fromhypertension, diabetes, hypothyroidism and post-infarction injury and to determine targets of examinedpharmacological and nonpharmacological compounds. This approach should reveal signaling pathways andfactors, whose modulation could hamper or reverse fibrosis. It is expected that findings of this preclinical studymay outline design of clinical trials how to protect the heart from its dysfunction by non-invasive way.
Duration: 1.1.2015 – 31.12.2018
Protekcia hypertenzného a zlyhávajúceho srdca blokátorom I(f) kanálu ivabradínom: porovnanie s ACE-inhibíciou a melatonímom
Protection of hypertensive and failure heart by I(f) channel blocker ivabradin: comparison with ACE inhibition and melatonin
Program: VEGA
Project leader: doc. RNDr. Pecháňová Oľga DrSc.
Duration: 1.1.2015 – 31.12.2018
Protektívne účinky prírodných a syntetických látok pred oxidačným poškodením vysokomolekulového hyalurónanu, izolovaných živočíšnych buniek a ich mitochondrií
Protective effects of natural and synthetic substances against oxidative damage of high-molar-mass hyaluronan, isolated mammal cells and their mitochondria
Program: VEGA
Project leader: RNDr. Valachová Katarína PhD.
Annotation: Hyaluronan (HA) is a polysaccharide of molar mass several megaDaltons present in tissues of vertebrates. In inflammatory diseases the average molar mass of HA decreases by action of oxidants. A significant decrease of synovial fluid (SF) viscoelasticity was detected, thereby its lubricating properties are worsened. High-molar-mass HA solutions are relevantly used for in vitro studies of free radicals and oxidants performance and also for a study of protective effects of antioxidants/drugs in a role of prevention or chain-breaking degradation of HA macromolecules.Substances of synthetic origin such as antiinflammatory drugs, mitochondria targeted antioxidants and natural substances with demonstrated antioxidative effects against HA degradation will be tested as protectors of oxidative degradation of cell lines of fibroblasts NIH-3T3, B-HNF-1, VH10 and cell organels, especially mitochondria.
Duration: 1.1.2015 – 31.12.2018
Protektívny účinok NO a CO donorov pri experimentálnom infarkte myokardu s hypertenzívnymi komplikáciami
Protective effect of NO and CO donors in experimental myocardial infarction with hypertensive complications
Program: VEGA
Project leader: doc. RNDr. Pecháňová Oľga DrSc.
Duration: 1.1.2015 – 31.12.2018
Redoxná regulácia profesionálnych fagocytov v krvi a v centrálnom nervovom systéme: Molekulárne mechanizmy a funkčný význam.
Redox control of the professional phagocytes in blood and in the central nervous system: Molecular mechanisms and functional significance.
Program: VEGA
Project leader: PharmDr. Jančinová Viera PhD.
Annotation: The submitted project is a continuation of our previous research in the pharmacological regulation of inflammatory processes. The focus is on neutrophils and microglial cells (resident brain macrophages) which are considered active participants in the initiation and progression of pathological states connected with chronic inflammation such as arthritis or neurodegenerative diseases. The aim of the project is to explain cellular and molecularmechanisms involved in the pharmacological modulation of these cells. Attention will be paid to drugs and derivatives of natural substances which are able to influence the production of reactive oxygen and nitrogen species. The coordinated research of two types of phagocytes creates an opportunity for the sharing of modern instruments and excellent methods as immunofluorescence microscopy or flow cytometry. Cooperation betweenbasic research and clinical practice will allow the use of these methods in the analysis of phagocytes from patients with rheumatoid arthritis.
Duration: 1.1.2016 – 31.12.2018
Rizikové faktory kardiovaskulárnych a cerebrovaskulárnych ochorení a farmakologické možnosti ich ovplyvnenia
Risk factors of cardiovascular and cerebrovascular diseases and pharmacological possibilities of their influence
Program: VEGA
Project leader: RNDr. Gáspárová Zdenka PhD.
Annotation: The project is aimed at the study of mechanisms of etiopathogenesis of metabolic syndrome (MS) and metabolic cognitive syndrome (MSC). The goal is to design new effective therapy affecting the origin and development of risk factors of cardiovascular and cerebrovascular diseases. Experiments will be performed on a genetic model of rats with hereditary hypertriglyceridemia, fed with hyperlipidemic diet. The induced metabolic disorders willbecome manifest by hypertension, hypercholesterolemia, hyperglycemia, hypertriglyceridemia, inflammatory reactions and increased markers of oxidative stress. Effect on the risk factors of MS and MCS, lipidic profile, on markers of damage at cellular and molecular level, function, behavioral and histopathological changes will be studied after repeated administration of the new pyridoindole SMe1EC2, flavonoid rutin, and atorvastatin as a standard. Action on several risk factors of cardiovascular and cerebrovascular diseases simultaneously is expected.
Duration: 1.1.2015 – 31.12.2018
Štúdium dôsledkov materskej depresie a podávania antidepresíva venlafaxínu na funkčný vývin mozgu a správanie potomstva potkanov
Study of consequences of maternal depression and antidepressant venlafaxine treatment on functional development of the brain and behavior of rat offspring
Program: VEGA
Project leader: RNDr. Dubovický Michal CSc.
Duration: 1.1.2015 – 31.12.2018
Vplyv konštitučných faktorov redoxnej regulácie na endofenotypové znaky schizofrénie
The influence of constitutional factors of redox regulation on endophenotypic markers of schizophrenia
Program: VEGA
Project leader: MUDr. Riečanský Igor PhD.
Annotation:
Duration: 1.1.2016 – 31.12.2018
Vplyv veku na senzorickú reguláciu rovnováhy pri vstávaní zo sedu a chôdzi
Age-related changes in sensory control of balance during sit-to-stand and gait
Program: VEGA
Project leader: Ing. Hlavačka František CSc.
Annotation: The ability to reliably perform functional movements like sit-to-stand, gait or maintaining the erect posture is a basis for the independent living. Difficulties with conducting these motor activities increase with age. Early diagnostics and suitable therapeutic interventions can help to moderate these problems and prevent falls. The goal of our project is to obtain new knowledge about the physiological mechanisms of sit-to-stand movement and gait in young and elderly adults, and also to expand information about the sensory influence on these motor functions. We will focus on analysis of balance control in static and dynamic conditions during sit-to-stand, step initiation and gait using unique 6-camera motion capture system BTS SMART-DX. We assume that results of our project would be worthwhile in designing of perspective rehabilitative methods for elderly people with mobility deficit to improve their balance and functional mobility, and also to enhance diagnostics of early stages of neurological disorders.
Duration: 1.1.2016 – 31.12.2018
KANASTA – Kardiovaskulárne účinky nanoenkapsulovaného simvastatínu a koenzýmu Q10 pri experimentálnej hyperlipidémii (KANASTA)
Cardiovascular Effects of Nanoencapsulated Simvastain and Coenzyme Q10 in Experimental Hyperlipidemia (KANASTA)
Program: Other projects
Project leader: RNDr. Reháková Radoslava
Annotation: The project is aimed to investigate cardiovascular effects of simvastatin together with CoQ10 in experimental hyperlipidemia and to increase bioavailability of simvastatin in the liver, thus reducing the daily dose and consequently to prevent the reduction of CoQ10 levels.
Duration: 27.11.2015 – 26.11.2018
Výskum inovatívnych liekových foriem a technologických postupov pri ekologickom spracovaní biologického odpadu vaječných škrupín
Program:
Project leader: RNDr. Dubovický Michal CSc.
Duration: 1.9.2015 – 31.8.2018