Research

Main interest of the Institute is focused on the study of chronic diseases with emphasis on pro-inflammatory processes with aim to develop new medical principles. Pharmacodynamic, biochemical as well as toxicological mechanisms of action of biologically active substances with anti-inflammatory and anti-radical properties are investigated at body, organ, cellular, membrane, receptor, and molecular levels.

Main Fields of Research:

Study of mechanisms of receptor as well as non-receptor interactions between cationic amphiphilic drugs and isolated cells at cellular and molecular levels especially the effect of these drugs on blood platelets, polymorphonuclear leukocytes and on their mutual interactions.

Study of the action of compounds affecting a generation and/or the action of reactive oxygen species on nervous tissue damaged due to oxidative stress.

Analysis of the mechanisms responsible for altered smooth muscle activity and endothelial and epithelial function, elicited by detrimental action of reactive oxygen species produced during pathological stages (e.g. ischaemia/reperfusion, diabetes mellitus, hypertension, arthritis).

Arthritis in rat induced by intradermal injection of mycobacterial adjuvant is used as a model for the evaluation of compounds with anti-inflammatory or anti-rheumatic activity and is an important methodological tool for studying the mechanism of rheumatoid arthritis.

Oxidative injury of Ca-ATPase from sarcoplasmic reticulum as a calcium regulatory enzyme in vitro and in the animal models of human diseases (rheumatoid arthritis, diabetes).

Application of various oxidative systems to study the degradation of high-molar-mass hyaluronan

Introduction of new methodologically, conceptually and computationally uniform modeling techniques into pharmacology.

Embryotoxicity/teratogenicity studies of new drugs in mice, rats and rabbits: research is focused on investigation of effects of drugs on intrauterine development of embryos and foetuses.

Chemical and biochemical approaches in studying metabolic pathways of xenobiotics: in vitro experimental data correlated with the situation in vivo. Chemical and enzyme mechanisms of molecular oxygen activation and tissue damage under hypoxic conditions.