The Laboratory of Bioorganic Chemistry of Drugs
Head of Laboratory
Ing. Katarína Valachová, PhD.
Hyaluronan (HA) is a polysaccharidic constituent of numerous tissues in the vertebrate organisms. One ml of synovial fluid (SF) – an essential joint component – contains 2-3 mg HA, which molar mass reaches in healthy adults the magnitude of about several megaDaltons. However, at the inflammatory joint disorders, the mean molar mass of HA is significantly decreased. This decrease is accompanied by a pronounced decline of the HA solution viscoelasticity and loss of the lubricating properties of SF. Low resistance of HA against the action of oxidative species – free radicals, anions – stimulated our efforts to use this biopolymer as a relevant (endogenic) substance for in vitro investigations of the “damaging” action of oxidants and/or for evaluation of the efficacy of various compounds/drugs to act as scavenging antioxidants.The substances such as antiinflammatory drugs, thiol substances, endogenous substances, pyridoindole derivatives and nutritional supplements which will have significant antioxidant effect against HA degradation will be tested in relation to their protective effect against damage of joint elements.
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