The Department of Biochemical Pharmacology

Head of Department

RNDr. Magdaléna Májeková, PhD.

Research

cukrDesign, development and testing new multi-target oriented compounds for a treatment and prevention of chronic disorders and diseases (chronic complications in diabetic patients, neurodegenerative diseases, oxidation stress related tissue damage).
Molecular targets: aldo-keto reductases, monoamine oxidases, Ca-ATPase from sarcoplasmic reticulum, reactive products of oxidation stress.
Chemical and enzyme mechanisms of molecular oxygen activation and tissue damage under hypoxic conditions. Toxic effects of reactive oxygen species and glucose under conditions of hyperglycemia with main attention to diabetic complications; enzyme mechanisms of poyol pathway in the ethiology of diabetic complications. Oxidative injury of Ca-ATPase from sarcoplasmic reticulum as a calcium regulatory enzyme . In silico approaches to antioxidant activity, ligand-protein interaction, QSAR and virtual screening.

Methods

Chemistry and biochemistry of biotransformation pathways of xenobiotics; inhibition, activation, induction and spectral properties of monooxygenases and reductases. Chemical and physico-chemical structural changes of lipids and proteins initiated by free radical attack. Cell culture techniques in studying cellular damage by oxidative and osmotic stress. Animal models of experimental diabetes and models of hypoxia-ischemia. Quantum chemical and molecular mechanics methods, QSAR, molecular dynamics.

People

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