The Department of Cellular Pharmacology and Developmental Toxicology

Head of Department

RNDr. Mojmír Mach, PhD.

Research focus

Developmental Toxicology and Pharmacology Unit

The broad area of research interest in our department involves studies to elucidate mechanisms of hypoxia during sensitive stages of development and involvement of drug during organogenesis and “fine tuning” of central nervous system. Using a variety of animal models of human diseases in conjunction with biochemical, histology and behavioral methods of analysis, we seek to determine the extent to which these early influences can change the quality of later life. Screening for new prospective psychoactive drugs is also one of the research focuses. The Department utilises a spectrum of standard toxicological and behavioral methods such as screening for developmental anomalies, neurodevelopmental analysis, imunohistochemical-based assessment, anxiety- and depression-like behaviour observations, cognition and social behaviour evaluation. The department disposes a modern equipment necessary for teratological and behavioural studies.

Cellular Pharmacology Unit

The laboratory is engaged in the study of mechanisms of receptor as well as non-receptor interactions between cationic amphiphilic drugs and isolated cells at cellular and molecular levels. Especially the effect of beta-adrenoceptor blocking and antihistamine drugs, stobadine and chloroquine on blood platelets, polymorphonuclear leukocytes and on their mutual interactions is studied. In the presence of drugs, alterations in functions of tested cells (aggregability, release reaction, free radical generation, myeloperoxidase and beta-glucuronidase release) as well as in some cellular regulatory mechanisms (calcium displacement and movement, arachidonic acid metabolism, histamine and serotonin liberation) are investigated. Pharmacological effects are correlated with the structure and physico-chemical properties of drugs studied.

Pharmacology of Excitable Tissues Unit

Analysis of the mechanisms responsible for altered smooth muscle activity and endothelial and epithelial function, elicited by detrimental action of reactive oxygen species produced during pathological stages (e.g. ischaemia/reperfusion, diabetes mellitus, hypertension, arthritis). By applying techniques of pharmacology and biochemistry, the modulatory action of some drugs with antioxidant and scavenging properties (e.g. pyridoindols, natural products, etc.) on the ROS-induced injury of smooth muscle functions is determined and characterised.
Cardiovascular pharmacology, cell signalling mechanisms in myocardial and vascular smooth muscle cells and in compromised myocardial tisues, use of animal experimental models.
Study of the action of compounds affecting a generation and/or the action of reactive oxygen species on central nervous tissue damaged due to oxidative stress. The main aim has been pharmacological protection of the nervous system against oxidative stress occurring in some acute and chronic neurological diseases. The problem is being analyzed on receptor, biochemical, cellular, tissue, and whole animal level.

Bioorganic Chemistry of Drugs Unit

Hyaluronan (HA) is a polysaccharidic constituent of numerous tissues in the vertebrate organisms. One ml of synovial fluid (SF) – an essential joint component – contains 2-3 mg HA, which molar mass reaches in healthy adults the magnitude of about several megaDaltons. However, at the inflammatory joint disorders, the mean molar mass of HA is significantly decreased. This decrease is accompanied by a pronounced decline of the HA solution viscoelasticity and loss of the lubricating properties of SF. Low resistance of HA against the action of oxidative species – free radicals, anions – stimulated our efforts to use this biopolymer as a relevant (endogenic) substance for in vitro investigations of the “damaging” action of oxidants and/or for evaluation of the efficacy of various compounds/drugs to act as scavenging antioxidants.The substances such as antiinflammatory drugs, thiol substances, endogenous substances, pyridoindole derivatives and nutritional supplements which will have significant antioxidant effect against HA degradation will be tested in relation to their protective effect against damage of joint elements.

Name / Position E-mail Phone
Belovičová, Kristína Mgr., PhD.

kristina.melichercikova@savba.sk 02/32295733
Bezek, Štefan MVDr., DrSc.

Senior Research Fellow
exfastbe@savba.sk 02/59410663
Blaškovič, Dušan RNDr., PhD.

Senior Research Fellow
dusan.blaskovic@gmail.com 02/32295721
Bögi, Eszter Mgr., PhD.

Junior Research Fellow
eszter.bogi@savba.sk 02/32295733
Brnoliaková, Zuzana Ing., PhD.

Senior Research Fellow
zuzana.brnoliakova@savba.sk 02/ 32 295 716, kl. 2716
Csátlosová, Kristína Mgr.

PhD. Student
kristina.csatlosova@savba.sk
Dubovický, Michal RNDr., CSc.

Director
exfadubm@savba.sk 02/32295700
Gáspárová, Zdenka RNDr., PhD.

exfagasp@savba.sk 02/32295714
Hodúrová, Zuzana Mgr., PhD.

Junior Research Fellow
zuzana.hodurova@savba.sk 02/32295708
Jančinová, Viera PharmDr., PhD.

Senior Research Fellow
exfavega@savba.sk 02/32295728
Kanďárová, Helena Dr.rer.nat., Ing., ERT

Senior Scientist
helena.kandarova@savba.sk 02/32295724
Kapoor, Sonam MSc

sonam.kapoor@savba.sk 02/32295719
Knezl, Vladimír RNDr., PhD.

Senior Research Fellow
exfaknem@savba.sk 02/59410677
Koprdová, Romana MVDr., PhD.

junior research fellow
romana.koprdova@savba.sk 02/32295743
Luptáková, Dominika Mgr.

junior research fellow
dominika.luptakova@savba.sk 02/32295708
Mačičková, Tatiana RNDr., CSc.

Senior Research Fellow
exfatama@savba.sk 02/32295727
Mach, Mojmír RNDr., PhD.

Deputy Director, Head of Department
mojmir.mach@savba.sk 02/32295718
Micháliková, Dominika Mgr.

PhD. Student
dominika.michalikova@savba.sk
Nosáľ, Radomír prof. MUDr., DrSc.

Senior Research Fellow
exfarano@savba.sk 02/32295725
Piešová, Michaela Mgr.

PhD. Student
michaela.piesova@savba.sk
Poláková, Júlia

Technician
julia.polakova@savba.sk 02/59410676
Račková, Lucia Ing., PhD.

Independent scientist (scientific degree IIa)
lucia.rackova@savba.sk 02/32295720
Regeš, Michal Mgr.

PhD. student
michal.reges@savba.sk
Sotníková, Ružena RNDr., CSc.

Senior Research Fellow
exfarosa@savba.sk 02/32295716
Srnová, Monika

Technician
exfamoni@savba.sk 02/59410663
Straková, Zuzana

Technician
exfapipa@savba.sk 02/32295727
Šimončičová, Eva Mgr.

eva.simoncicova@savba.sk 02/32295743
Škandík, Martin Ing.

martin.skandik@savba.sk
Šoltés, Ladislav Ing., DrSc.

Senior Research Fellow
exfasolt@savba.sk 02/32295706
Švecová, Blanka Ing.

blanka.reingraberova@savba.sk 0232295743
Ujházy, Eduard Doc. RNDr., CSc.

Senior Research Fellow
exfaujha@savba.sk 02/32295717
Valachová , Katarína RNDr. , PhD.

scientist
katarina.valachova@savba.sk 02/32295707
Vandáková, Katarína

Technician
02/59410677
Zborovanová, Dana

Technician
02/59410664