Departments

The Institute of Experimental Pharmacology & Toxicology provides expert-opinion reports and consultations in the following areas:

  • screening antioxidant and free radical scavenging activities of new antioxidants
  • enzyme content and activity assays: cytochrome P-450, cytochrome b5, NADPH-cytochrome-P-450-reductase, superoxide dismutase
  • quantum-chemistry analyses
  • QSAR studies of drugs
  • cellular and molecular effects of drugs (including new potential drugs) on isolated human and animal cells
  • functions of blood platelets and polymorphonuclear leukocytes in patients suffering from cardiovascular, liver or neurological diseases
  • neuronal excitability, synaptic transmission and long-term potentiation of synaptic transmission (hippocampal slices)
  • biochemistry of nervous tissue (enzymes and metabolic markers, e.g. SOD, GPX, CAT, LDH, Na,K-ATPase, GMT, ATP, CP, alpha-HG, MDA, GSH)
  • neurological status of experimental animals
  • a formal description of the disposition data can be suggested based on compartmental and noncompartmental methods
  • rate and extent of bioavailability of the drug can be investigated in the beagle dog, including comparison of the in vitro and in vivo parameters
  • pharmacology of the autonomous nervous system
  • action of free radicals on smooth muscle tissues
  • screening of drugs acting on smooth muscles (e.g. spasmolytics, anticholinergics, adrenotropic drugs, antihistaminics)
  • preclinical research and expert evaluation of new pharmacologically active drugs affecting the cardiovascular system, coronary circulation and heart muscle
  • consultations in cardiovascular pharmacology, animal experimental models and cardiotoxicity
  • side effects of drugs affecting cardiovascular system
  • complex reproductive studies (mouse, rat, rabbit)
  • evaluation of fertility (Segment I)
  • embryotoxicity and teratogenity (Segment II)
  • neurobehavioural development of offspring (Segment III)
  • consultations in projection and building of breeding facilities and animal rooms
  • consultations in laboratory animal medicine
  • preparation of any experimental or test diet
  • a wide range of experience in reproductive and developmental toxicology studies in rodent and non-rodent species