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Departments
The Institute of Experimental Pharmacology & Toxicology provides expert-opinion reports and consultations in the following areas:
- screening antioxidant and free radical scavenging activities of new antioxidants
- enzyme content and activity assays: cytochrome P-450, cytochrome b5, NADPH-cytochrome-P-450-reductase, superoxide dismutase
- quantum-chemistry analyses
- QSAR studies of drugs
- cellular and molecular effects of drugs (including new potential drugs) on isolated human and animal cells
- functions of blood platelets and polymorphonuclear leukocytes in patients suffering from cardiovascular, liver or neurological diseases
- neuronal excitability, synaptic transmission and long-term potentiation of synaptic transmission (hippocampal slices)
- biochemistry of nervous tissue (enzymes and metabolic markers, e.g. SOD, GPX, CAT, LDH, Na,K-ATPase, GMT, ATP, CP, alpha-HG, MDA, GSH)
- neurological status of experimental animals
- a formal description of the disposition data can be suggested based on compartmental and noncompartmental methods
- rate and extent of bioavailability of the drug can be investigated in the beagle dog, including comparison of the in vitro and in vivo parameters
- pharmacology of the autonomous nervous system
- action of free radicals on smooth muscle tissues
- screening of drugs acting on smooth muscles (e.g. spasmolytics, anticholinergics, adrenotropic drugs, antihistaminics)
- preclinical research and expert evaluation of new pharmacologically active drugs affecting the cardiovascular system, coronary circulation and heart muscle
- consultations in cardiovascular pharmacology, animal experimental models and cardiotoxicity
- side effects of drugs affecting cardiovascular system
- complex reproductive studies (mouse, rat, rabbit)
- evaluation of fertility (Segment I)
- embryotoxicity and teratogenity (Segment II)
- neurobehavioural development of offspring (Segment III)
- consultations in projection and building of breeding facilities and animal rooms
- consultations in laboratory animal medicine
- preparation of any experimental or test diet
- a wide range of experience in reproductive and developmental toxicology studies in rodent and non-rodent species