Departments

The Institute of Experimental Pharmacology & Toxicology provides expert-opinion reports and consultations in the following areas:

screening antioxidant and free radical scavenging activities of new antioxidants
enzyme content and activity assays: cytochrome P-450, cytochrome b5, NADPH-cytochrome-P-450-reductase, superoxide dismutase
quantum-chemistry analyses
QSAR studies of drugs
cellular and molecular effects of drugs (including new potential drugs) on isolated human and animal cells
functions of blood platelets and polymorphonuclear leukocytes in patients suffering from cardiovascular, liver or neurological diseases
neuronal excitability, synaptic transmission and long-term potentiation of synaptic transmission (hippocampal slices)
biochemistry of nervous tissue (enzymes and metabolic markers, e.g. SOD, GPX, CAT, LDH, Na,K-ATPase, GMT, ATP, CP, alpha-HG, MDA, GSH)
neurological status of experimental animals
a formal description of the disposition data can be suggested based on compartmental and noncompartmental methods
rate and extent of bioavailability of the drug can be investigated in the beagle dog, including comparison of the in vitro and in vivo parameters
pharmacology of the autonomous nervous system
action of free radicals on smooth muscle tissues
screening of drugs acting on smooth muscles (e.g. spasmolytics, anticholinergics, adrenotropic drugs, antihistaminics)
preclinical research and expert evaluation of new pharmacologically active drugs affecting the cardiovascular system, coronary circulation and heart muscle
consultations in cardiovascular pharmacology, animal experimental models and cardiotoxicity
side effects of drugs affecting cardiovascular system
complex reproductive studies (mouse, rat, rabbit)
evaluation of fertility (Segment I)
embryotoxicity and teratogenity (Segment II)
neurobehavioural development of offspring (Segment III)
consultations in projection and building of breeding facilities and animal rooms
consultations in laboratory animal medicine
preparation of any experimental or test diet
a wide range of experience in reproductive and developmental toxicology studies in rodent and non-rodent species