Xth. Minicoference of PhD. students of the Centre of Experimental Medicine

Dear colleagues!
On behalf of the organizing committee, we are pleased to welcome you to the Xth Miniconference of PhD. students of Centre of Experimental Medicine, Slovak Academy of Sciences. This conference is organized by fourth-year’s PhD. students. Due to the ongoing COVID-19 pandemic situation, the conference will be held online this year, for the second time in its history. Authors will present their work online through the ZOOM platform with consecutive live discussions related to the topic. This Book of Abstracts contains the program and abstracts of the lectures presented at the Xth Miniconference of PhD. Students. Moreover, it is assigned with an ISBN number to enrich the publication list of all participants. We want to thank the authors for their contributions. Traditionally, the Miniconference has provided a platform, where the PhD. students can get inspiration for their scientific work and improve their presentation skills in English. We hope that this year’s event, too, will encourage young scientists to continue their hard work despite all the obstacles they may encounter during this pandemic situation.

The Organising Committee

Programme
Book of abstracts

HOT TOPICS

Cemtirestat, a novel aldose reductase inhibitor and antioxidant, in multitarget pharmacology of diabetic complications

jm-2014-015814_0007Fifteen compounds, sharing an indole-1-acetic acid moiety as a common fragment, were selected from commercial databases for testing aldose reductase inhibition. 3-Mercapto-5H-1,2,4-triazino[5,6-b]indole-5-acetic acid was the most promising inhibitor, with an IC50 in the submicromolar range and high selectivity, relative to aldehyde reductase. The crystal structure of aldose reductase complexed with cemtirestat revealed an interaction pattern explaining its high affinity. Physicochemical parameters underline the excellent “leadlikeness” of cemtirestat as a promising candidate for further structure optimizations.
DOI: 10.1021/jm5015814
http://pubs.acs.org/doi/abs/10.1021/jm5015814

Influence of tiopronin, captopril and levamisole therapeutics on the oxidative degradation of hyaluronan

The results of ABTS and DPPH assays show the highest radical scavenging activity for captopril, followed by tiopronin. For levamisole, no effect was observed. Captopril and tiopronin prevented hyaluronan degradation induced by •OH radicals in a similar manner, while tiopronin was more effective in scavenging peroxy-type radicals.
Read the Article

A new mechanism involved in the anti-inflammatory activity of hydroxychloroquine

neutrofilHydroxychloroquine is used in the therapy of rheumatoid arthritis or lupus erythematosus. Although these diseases are often accompanied by activation of neutrophils, there are still few data relating to the impact of hydroxychloroquine on these cells. We investigated the effect of orally administered hydroxychloroquine on neutrophil oxidative burst in rats with adjuvant arthritis.
Read the Article

Therapeutic potential of 3′-O-(3-chloropivaloyl)quercetin as a novel antiinflammatory drug in neurodegenerative diseases

BV-2Chronic inflammation in brain plays a critical role in major neurodegenerative diseases such as Alzheimer’s, Parkinson’s disease, stroke or multiple sclerosis. Microglia, resident macrophages and intristinc components of CNS, appear to be main effectors in this pathological process. Quercetin, a naturally occurring flavonoid, was proven to downregulate inflammatory genes in microglia. Synthetically modified quercetin, 3′-O-(3-chloropivaloyl) quercetin (CPQ), is assumed to possess better biological availability and enhanced antioxidant properties.
Read the Article

Recent News

Čarovná cesta vzniku nového lieku

Deň otvorených dverí 9. 11.2016 o 9:00 Tajomnou cestou vzniku nového lieku Vás prevedú vedci z Ústavu experimentálnej farmakológie a toxikológie SAV. Zoznámite sa s Read More ...

SME live: Can alternative medicine replace drugs?

Does every alternative medicine represents empiricism? Does it work, or it is placebo effect only? Watch the discussion where our scientist Dr. Majeková debate about Read More ...

SDS Award for our Scientists

Ing. Marta Šoltésová Prnová, PhD., Ing. Milan Štefek, PhD and co-authors from Dept. of  Biochemical Pharmacology received Slovak Diabetologic Society Award for their experimental research Read More ...

SCImago Journal & Country Rank